Palladium-mediated synthesis of 1,1,2-triarylethanes. Application to the synthesis of CDP-840
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.01.030
Abstract: Abstract A three-step protocol toward 1,1,2-triarylethanes 1 starting with β-ketosulfones 2 is developed. A facile process is carried out for the (1) reduction of 2 with NaBH4, (2) BF3·OEt2-mediated Friedel-Crafts reactions of the resulting β-hydroxy… read more here.
Keywords: synthesis cdp; cdp 840; palladium mediated; mediated synthesis ... See more keywords
Specific and Reversible Enrichment of Early-Stage Glycated Proteome Based on Thiazolidine Chemistry and Palladium-Mediated Cleavage.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03648
Abstract: Comprehensive analysis of protein glycation is important for better understanding of its formation mechanism and biological significance. The current preconcentration methods of glycated proteome mainly depend on the reversible combination of boronic acid and cis-dihydroxy… read more here.
Keywords: glycated proteome; chemistry; thiazolidine chemistry; mediated cleavage ... See more keywords
Palladium-Mediated Functionalization of Benzofuran and Benzothiophene Cores
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DOI: 10.1021/acs.organomet.8b00682
Abstract: The palladation reactions of 2-heteroaromatic primary phenethylamines bearing a benzofuran and benzothiophene nuclei have been studied. We have assessed the reactivity of the corresponding dimeric six-membered palladacycles (arising from C–H metalation) toward neutral ligands and… read more here.
Keywords: benzofuran benzothiophene; mediated functionalization; functionalization benzofuran; palladium mediated ... See more keywords
A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc00865a
Abstract: A new palladium mediated "one pot" synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was discovered by gas-phase experiments and theoretical studies. Palladium-mediated decarboxylation of aromatic carboxylic acids followed… read more here.
Keywords: discovered gas; studies palladium; palladium mediated; one pot ... See more keywords
Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage
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DOI: 10.1039/d1ra09180h
Abstract: Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions… read more here.
Keywords: cleavage; self immolative; dna; palladium mediated ... See more keywords