Chemerin induced by Treponema pallidum predicted membrane protein Tp0965 mediates the activation of endothelial cell via MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29269
Abstract: Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with Treponema pallidum.… read more here.
Keywords: protein; tp0965; signaling pathway; endothelial cells ... See more keywords
Histamine Excites Rat GABAergic Ventral Pallidum Neurons via Co-activation of H1 and H2 Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-018-0277-8
Abstract: The ventral pallidum (VP) is a crucial component of the limbic loop of the basal ganglia and participates in the regulation of reward, motivation, and emotion. Although the VP receives afferent inputs from the central… read more here.
Keywords: histaminergic system; central histaminergic; histamine excites; ventral pallidum ... See more keywords
The P2X7 receptor mediates NLRP3-dependent IL-1β secretion and promotes phagocytosis in the macrophage response to Treponema pallidum.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106344
Abstract: It is unclear whether P2X7 receptor (P2X7R) mediates NOD-like receptor family protein 3 (NLRP3)-dependent IL-1β secretion and spirochete phagocytosis in syphilis. This study was conducted to investigate the role of P2X7R in modifying NLRP3-dependent IL-1β… read more here.
Keywords: secretion; dependent secretion; nlrp3 dependent; p2x7 receptor ... See more keywords
Virulence and Adhesion of the Treponema pallidum Nichols Strain Simultaneously Decrease in a Continuous-Infection New Zealand White Rabbit Model.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00601
Abstract: Syphilis is a sexually transmitted disease caused by T. pallidum, and the T. pallidum Nichols strain is widely used with the New Zealand white rabbit model for evaluating drug and vaccine protection. However, changes in… read more here.
Keywords: new zealand; virulence; pallidum; rabbit model ... See more keywords
A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14273
Abstract: Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here… read more here.
Keywords: treponema pallidum; vaccine candidate; syphilis vaccine; vaccine ... See more keywords
Treponema pallidum outer membrane proteins: current status and prospects.
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens and disease"
DOI: 10.1093/femspd/ftac023
Abstract: The outer membrane proteins (OMPs) of Treponema pallidum subsp. Pallidum (T. pallidum), the etiological agent of the sexually transmitted disease syphilis, has long been a hot research topic. Despite many hurdles to studying the pathogen, especially the inability to manipulate T.… read more here.
Keywords: membrane proteins; pallidum; outer membrane; treponema pallidum ... See more keywords
Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab318
Abstract: Abstract The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum… read more here.
Keywords: evolutionary processes; treponema pallidum; pallidum; agent ... See more keywords
Treponema pallidum membrane protein Tp47 promotes angiogenesis through ROS‐induced autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18728
Abstract: Pathological angiogenesis is an important manifestation of syphilis, but the underlying mechanism of Treponema pallidum subspecies pallidum (T. pallidum)‐induced angiogenesis is poorly understood. read more here.
Keywords: pallidum; pallidum membrane; membrane protein; treponema pallidum ... See more keywords
Characterization of Treponema denticola Major Surface Protein (Msp) by Deletion Analysis and Advanced Molecular Modeling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00228-22
Abstract: The Treponema denticola gene encoding its major surface protein (Msp) is an ortholog of the T. pallidum tprA to -K gene family that includes tprK, whose remarkable in vivo hypervariability is proposed to contribute to… read more here.
Keywords: pallidum; denticola; surface; treponema ... See more keywords
Long-Term In Vitro Culture of the Syphilis Spirochete Treponema pallidum subsp. pallidum
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DOI: 10.1128/mbio.01153-18
Abstract: ABSTRACT Investigation of Treponema pallidum subsp. pallidum, the spirochete that causes syphilis, has been hindered by an inability to culture the organism continuously in vitro despite more than a century of effort. In this study,… read more here.
Keywords: treponema pallidum; long term; culture; pallidum ... See more keywords
Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. pallidum
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02726-20
Abstract: Syphilis continues to be a significant public health issue in both low- and high-income countries, including the United States where the rate of syphilis infection has increased over the past 5 years. Treponema pallidum subsp.… read more here.
Keywords: pallidum subsp; pallidum; full length; subsp pallidum ... See more keywords