Effect of glucose and palmitate environment on proliferation and migration of PC3‐prostate cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11066
Abstract: Recent studies have been trying to find out how diet and metabolic changes such as dyslipidaemia, hyperglycaemia, and hyperinsulinaemia can stimulate cancer progression. This investigation aimed to evaluate the effect of high concentrations of fatty… read more here.
Keywords: proliferation migration; palmitate; proliferation; effect ... See more keywords
Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048651
Abstract: Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune… read more here.
Keywords: jmjd3; histone demethylase; palmitate; inflammation ... See more keywords
Compositional Changes Among Triglycerides and Phospholipids During FATP4 Sensitization with Palmitate Lead to ER Stress in Cultured Cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Lipid Science and Technology"
DOI: 10.1002/ejlt.201800394
Abstract: FATP4 expression is upregulated in acquired obesity and polymorphisms in the FATP4 gene are associated with increased blood triglycerides (TG). Since non‐alcoholic fatty liver disease (NAFLD) is a manifestation of obesity, it is of interest… read more here.
Keywords: response; palmitate; compositional changes; stress ... See more keywords
Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0059-4
Abstract: The brain is very sensitive to metabolic dysfunctions induced by diets high in saturated fatty acids, leading to neuroinflammation. The liraglutide has been found to have neuroprotective effects. However, its neuroprotective action in a model… read more here.
Keywords: liraglutide glp1; palmitate; inflammation; beneficial effects ... See more keywords
The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.077
Abstract: Elevated plasma free fatty acid (FFA) levels are associated with insulin resistance and can cause lipotoxicity in skeletal muscles. In response to FFAs, skeletal muscle can secrete a variety of cytokines. Irisin, one such muscle-secreted… read more here.
Keywords: fndc5; palmitate; smad3; expression ... See more keywords
Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.072
Abstract: Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, and higher risk of developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largely unknown. Here,… read more here.
Keywords: palmitate; palmitate increased; impairment mice; increased cerebrospinal ... See more keywords
Lipase-Catalyzed Synthesis of Sn-2 Palmitate: A Review
Sign Up to like & getrecommendations! Published in 2020 at "Engineering"
DOI: 10.1016/j.eng.2020.02.008
Abstract: Abstract Human milk fat (HMF) is an important source of nutrients and energy for infants. Triacylglycerols (TAGs) account for about 98% of HMF and have a unique molecular structure. HMF is highly enriched in palmitic… read more here.
Keywords: lipase catalyzed; palmitate; hmf; synthesis palmitate ... See more keywords
Temperature-tuned selectivity to alkanes or alcohol from ethyl palmitate deoxygenation over zirconia-supported cobalt catalyst
Sign Up to like & getrecommendations! Published in 2020 at "Fuel"
DOI: 10.1016/j.fuel.2020.118295
Abstract: Abstract Highly active Co/ZrO2 catalysts were synthesized for the conversion of ethyl palmitate to alcohol or diesel-like alkanes, with high yield and tunable selectivity, controlled by reaction temperature. The formation of hexadecanol was favored at… read more here.
Keywords: temperature; palmitate; deoxygenation; yield ... See more keywords
Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.03.011
Abstract: Lipotoxicity plays an important role in the progression of chronic kidney damage via various mechanisms, such as endoplasmic reticulum stress. Several studies proposed renal lipotoxicity in glomerular and tubular cells but the effect of lipid… read more here.
Keywords: production; endoplasmic reticulum; palmitate; atf4 activation ... See more keywords
Obesity-related cellular stressors regulate gonadotropin releasing hormone gene expression via c-Fos/AP-1
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.07.011
Abstract: Obesity is a risk factor for infertility, but mechanisms underlying this risk are unclear. Fertility is regulated by hypothalamic gonadotropin-releasing hormone, encoded by the Gnrh1 gene. Because obesity promotes endoplasmic reticulum (ER) stress, we sought… read more here.
Keywords: releasing hormone; gonadotropin releasing; palmitate; expression ... See more keywords
Capmatinib improves insulin sensitivity and inflammation in palmitate-treated C2C12 myocytes through the PPARδ/p38-dependent pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111364
Abstract: Capmatinib (CAP) has been used to treat metastatic non-small lung cancer (NSCL) and suppress inflammation. It causes hypoglycemia in NSCL patients. Therefore, it is expected that CAP improves inflammation-mediated insulin resistance due to its anti-inflammatory… read more here.
Keywords: palmitate treated; palmitate; treated c2c12; inflammation ... See more keywords