LNK deficiency aggravates palmitate-induced preadipocyte apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.057
Abstract: LNK (SH2B3) is an intracellular adaptor protein that negatively regulates cellular proliferation or self-renewal of hematopoietic stem cells and some other progenitor cells. LNK is also recognized as a key regulator of insulin resistance and… read more here.
Keywords: apoptosis; palmitate induced; lnk; tissue ... See more keywords
Tst gene mediates protection against palmitate-induced inflammation in 3T3-L1 adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.014
Abstract: Abstract Obesity is a disease characterized by chronic inflammation and increases the risk of comorbidities such as type 2 diabetes mellitus, non-alcoholic fatty liver disease and cardiovascular dysfunction. In obese individuals, elevated levels of plasma… read more here.
Keywords: induced inflammation; palmitate induced; inflammation; 3t3 adipocytes ... See more keywords
Puerarin attenuates palmitate‐induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.05.041
Abstract: Aims: High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in… read more here.
Keywords: palmitate induced; dysfunction; inflammation; mitochondrial dysfunction ... See more keywords
Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition research"
DOI: 10.1016/j.nutres.2017.03.005
Abstract: Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism remains to be clearly elucidated. Palmitate is the most abundant SFA… read more here.
Keywords: nicotinamide supplementation; autophagy induction; anti lipotoxic; palmitate induced ... See more keywords
Palmitate-induced autophagy liberates monounsaturated fatty acids and increases Agrp expression in hypothalamic cells
Sign Up to like & getrecommendations! Published in 2019 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2019.1696407
Abstract: ABSTRACT Fatty acids regulate food intake, although the exact mechanism remains unknown. Emerging evidence suggests that intracellular free fatty acids generated by starvation-induced autophagy regulate food intake. Starvation for 6 h elevated fatty acids such as… read more here.
Keywords: palmitate induced; fatty acids; agrp expression; induced autophagy ... See more keywords
Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology"
DOI: 10.1159/000487892
Abstract: Hepatic lipid accumulation and apoptosis is elevated in patients with non-alcoholic steatohepatitis and is closely associated with severity. Saturated fatty acid palmitate stimulates lipid accumulation and apoptosis in hepatocytes. In the present study, we examined… read more here.
Keywords: lipid accumulation; palmitate induced; bee; accumulation apoptosis ... See more keywords
451-P: SGLT2 Inhibitor Protects Cardiomyocytes against Palmitate-Induced Lipotoxicity by Increasing Activation of AMPK and Lipid Oxidations
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-451-p
Abstract: Aim: This study was designed to evaluate the effects of SGLT2 inhibitor on palmitate-induced lipotoxicity of cardiomyocytes and the underlying mechanism involved with palmitate. Methods: We checked SGLT2 expression in muscle cells, including H9C2. H9C2… read more here.
Keywords: none; insulin; sglt2 inhibitor; palmitate induced ... See more keywords
Kidney Injury Molecule-1 Is Upregulated in Renal Lipotoxicity and Mediates Palmitate-Induced Tubular Cell Injury and Inflammatory Response
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143406
Abstract: Diabetic nephropathy is increasingly recognized as a major contributor to kidney failure in patients with obesity and type 2 diabetes. This study was designed to identify the molecular mediators of kidney injury associated with metabolic… read more here.
Keywords: kidney injury; palmitate induced; upregulated renal; injury molecule ... See more keywords
Effect of cis- and trans-Monounsaturated Fatty Acids on Palmitate Toxicity and on Palmitate-induced Accumulation of Ceramides and Diglycerides
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21072626
Abstract: Dietary trans fatty acids (TFAs) have been implicated in serious health risks, yet little is known about their cellular effects and metabolism. We aim to undertake an in vitro comparison of two representative TFAs (elaidate… read more here.
Keywords: cis; accumulation; palmitate toxicity; palmitate ... See more keywords
BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065657
Abstract: Diabetes is a chronic disease that affects glucose metabolism, either by autoimmune-driven β-cell loss or by the progressive loss of β-cell function, due to continued metabolic stresses. Although both α- and β-cells are exposed to… read more here.
Keywords: bcl overexpression; palmitate induced; overexpression; cell ... See more keywords
HM-Chromanone, a Major Homoisoflavonoid in Portulaca oleracea L., Improves Palmitate-Induced Insulin Resistance by Regulating Phosphorylation of IRS-1 Residues in L6 Skeletal Muscle Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14183815
Abstract: This study investigated the effect of (E)-5-hydroxy-7-methoxy-3-(2-hydroxybenzyl)-4-chromanone (HM-chromanone) on palmitate-induced insulin resistance and elucidated the underlying mechanism in L6 skeletal muscle cells. Glucose uptake was markedly decreased due to palmitate-induced insulin resistance in these cells;… read more here.
Keywords: muscle cells; insulin resistance; phosphorylation; palmitate induced ... See more keywords