LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "palmitoyl transferase" as a keyword



Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors

Sign Up to like & get
recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12196

Abstract: Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis‐dependent… read more here.

Keywords: spt inhibitors; serine palmitoyl; palmitoyl transferase; biologically annotated ... See more keywords

The serine palmitoyl transferase of plant pathogenic fungi: a promising new target for the development of novel crop protection solutions†

Sign Up to like & get
recommendations! Published in 2025 at "Pest Management Science"

DOI: 10.1002/ps.70014

Abstract: Plant pathogens pose a significant threat to global agriculture and, thus to world food supplies, requiring the development of fungicides with new modes of action. Pyridazine carboxamides (PCs) represent a novel class of fungicides that… read more here.

Keywords: palmitoyl transferase; development; serine palmitoyl; transferase plant ... See more keywords

Sudden infant death from neonate carnitine palmitoyl transferase II deficiency.

Sign Up to like & get
recommendations! Published in 2017 at "Forensic science international"

DOI: 10.1016/j.forsciint.2017.06.020

Abstract: A full-term female baby born to parents who gave birth three years prior to a girl who survived only 31h postpartum died 36h after birth. An autopsy showed that the heart was markedly hypertrophic (32g).… read more here.

Keywords: palmitoyl transferase; carnitine palmitoyl; deficiency; carnitine ... See more keywords

A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation

Sign Up to like & get
recommendations! Published in 2024 at "Nature Biotechnology"

DOI: 10.1038/s41587-023-02030-0

Abstract: The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here we present a… read more here.

Keywords: palmitoyl transferase; acylation; zdhhc; genetic system ... See more keywords