Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins
Sign Up to like & getrecommendations! Published in 2019 at "Biology Open"
DOI: 10.1242/bio.040311
Abstract: ABSTRACT In human, loss of acid sphingomyelinase (ASM/SMPD1) causes Niemann–Pick disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. Our mass spectrometry-based proteomic analyses have identified >100… read more here.
Keywords: plasma membrane; acid sphingomyelinase; palmitoylated proteins; regulates localization ... See more keywords
The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells
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DOI: 10.3389/fnmol.2017.00266
Abstract: CLN1 disease (OMIM #256730) is an early childhood ceroid-lipofuscinosis associated with mutated CLN1, whose product Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme involved in the removal of palmitate residues from S-acylated proteins. In neurons,… read more here.
Keywords: networks genes; synaptic compartments; axonal synaptic; encoding palmitoylated ... See more keywords
Chemical probe mediated visualization of protein S-palmitoylation in patient tissue samples
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1063247
Abstract: While protein palmitoylation has been studied for decades, our understanding of its clinical importance is minimal compared to other post translational modifications. As a result of the inherent challenges preventing the production of antibodies to… read more here.
Keywords: abe assay; palmitoylated proteins; protein palmitoylation; palmitoylation ... See more keywords