Palmitoylation in apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31047
Abstract: Palmitoylation, a critical lipid modification of proteins, is involved in various physiological processes such as altering protein localization, transport, and stability, which perform essential roles in protein function. Palmitoyltransferases are specific enzymes involved in the… read more here.
Keywords: modification; apoptosis; physiology; palmitoylation apoptosis ... See more keywords
In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12379
Abstract: S‐palmitoylation is a reversible posttranslational modification in which a 16‐carbon saturated fatty acid (generally palmitate) is attached to specific cysteine residues in polypeptides via thioester linkage. Dynamic S‐palmitoylation (palmitoylation‐depalmitoylation), like phosphorylation‐dephosphorylation, regulates the function of… read more here.
Keywords: palmitoylation; incl; apt1; proliferation ... See more keywords
Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C‐terminal palmitoylation‐deficient mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12044
Abstract: AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post‐translational protein S‐palmitoylation of AMPA receptor GluA subunits at their C‐termini reversibly controls the receptors trafficking to and from excitatory glutamatergic synapses. Excitatory… read more here.
Keywords: palmitoylation; dentate gyrus; immediate early; expression ... See more keywords
S-Acylation of Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9055-9_17
Abstract: Palmitoylation or S-acylation is the posttranslational attachment of fatty acids to cysteine residues and is common among integral and peripheral membrane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect,… read more here.
Keywords: protein; palmitoylation; acylation proteins; fatty acids ... See more keywords
Quantitative Analysis of Protein S-Acylation Site Dynamics Using Site-Specific Acyl-Biotin Exchange (ssABE).
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9232-4_6
Abstract: Protein S-acylation (palmitoylation) is a reversible lipid modification that is increasingly recognized as an important regulator of protein function, including membrane association, trafficking, and subcellular localization. Most proteomic methods to study palmitoylation allow characterization of… read more here.
Keywords: palmitoylation; protein acylation; site; acyl biotin ... See more keywords
CCN3 secretion is regulated by palmitoylation via ZDHHC22.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.128
Abstract: Normal extracellular secretion of nephroblastoma overexpressed (NOV, also known as CCN3) is important for the adhesion, migration, and differentiation of cells. In previous studies, we have shown that the intracellular accumulation of CCN3 inhibits the… read more here.
Keywords: palmitoylation; secretion; zdhhc22; ccn3 secretion ... See more keywords
Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TF
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2019.04.098
Abstract: Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. Although the protein-protein interactions (PPIs) between nonstructural proteins of CHIKV have been extensively established, the complete CHIKV intraviral interactome remains… read more here.
Keywords: palmitoylation; homo oligomerization; chikv; intraviral interactome ... See more keywords
KChIP2 Serves Multiple Functions in Cardiac Myocytes in Splice Isoform-Dependent Manner
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.230
Abstract: K-channel-interacting-proteins (KChIPs) are EF-hand-motif-bearing Ca sensors that serve diverse functions. KChIP2 is the major KChIP expressed in the heart, that can modulate key cardiac channels (Itof, Nav, CaV and IKur) by directly interacting with their… read more here.
Keywords: kchip2 serves; palmitoylation; kchip2c; kchip2a ... See more keywords
TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Virology"
DOI: 10.1016/j.virol.2020.01.001
Abstract: Sindbis virus (SINV) produces the small membrane protein TF from the 6K gene via a (-1) programmed ribosomal frameshifting. While several groups have shown that TF-deficient virus exhibits reduced virulence, the mechanism(s) by which this… read more here.
Keywords: palmitoylation; interferon; host; type ... See more keywords
S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00176
Abstract: Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV), and severe acute respiratory… read more here.
Keywords: sterol interactions; virus; palmitoylation sterol; specificity ... See more keywords
Dynamic Palmitoylation of Red Cell Membrane Proteins Governs Susceptibility to Invasion by the Malaria Parasite, Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00199
Abstract: Phosphorylation and other post-translational modifications of red blood cell (RBC) proteins govern membrane function and have a role in the invasion of RBCs by the malaria parasite, Plasmodium falciparum. Furthermore, a percentage of RBC proteins… read more here.
Keywords: rbc; membrane proteins; invasion; parasite invasion ... See more keywords