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   Articles with "palmitoylation" as a keyword



Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202412895

Abstract: High serum level of palmitic acid(PA) is implicated in pathogenesis of cardiovascular diseases. PA serves as the substrate for protein palmitoylation. However, it is still unknown whether palmitoylation is involved in PA‐induced cardiovascular dysfunction. Here,… read more here.

Keywords: induced endothelial; palmitoylation; dysfunction; palmitic acid ... See more keywords

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500218

Abstract: Protein S‐palmitoylation is a reversible posttranslational modification transferring the 16‐carbon fatty acid palmitate to cysteines. It plays a critical role in many cellular processes by influencing protein function, localization, stability, and protein–protein interactions and has… read more here.

Keywords: design peptides; palmitoylation; cell; toward design ... See more keywords

TLR9‐Driven S‐Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets

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recommendations! Published in 2025 at "European Journal of Immunology"

DOI: 10.1002/eji.70039

Abstract: Dendritic cells (DCs) rely on Toll‐like receptor 9 (TLR9) to detect unmethylated CpG motifs in microbial DNA, triggering essential immune responses. While the downstream signaling pathways of TLR9 activation are well characterized, their impact on… read more here.

Keywords: immune metabolic; protein targets; palmitoylation; dendritic cells ... See more keywords

Palmitoylation in apoptosis.

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recommendations! Published in 2023 at "Journal of cellular physiology"

DOI: 10.1002/jcp.31047

Abstract: Palmitoylation, a critical lipid modification of proteins, is involved in various physiological processes such as altering protein localization, transport, and stability, which perform essential roles in protein function. Palmitoyltransferases are specific enzymes involved in the… read more here.

Keywords: modification; apoptosis; physiology; palmitoylation apoptosis ... See more keywords

In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation

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recommendations! Published in 2021 at "Journal of Inherited Metabolic Disease"

DOI: 10.1002/jimd.12379

Abstract: S‐palmitoylation is a reversible posttranslational modification in which a 16‐carbon saturated fatty acid (generally palmitate) is attached to specific cysteine residues in polypeptides via thioester linkage. Dynamic S‐palmitoylation (palmitoylation‐depalmitoylation), like phosphorylation‐dephosphorylation, regulates the function of… read more here.

Keywords: palmitoylation; incl; apt1; proliferation ... See more keywords

Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C‐terminal palmitoylation‐deficient mice

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recommendations! Published in 2019 at "Neuropsychopharmacology Reports"

DOI: 10.1002/npr2.12044

Abstract: AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post‐translational protein S‐palmitoylation of AMPA receptor GluA subunits at their C‐termini reversibly controls the receptors trafficking to and from excitatory glutamatergic synapses. Excitatory… read more here.

Keywords: palmitoylation; dentate gyrus; immediate early; expression ... See more keywords

S-Acylation of Proteins.

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recommendations! Published in 2019 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-9055-9_17

Abstract: Palmitoylation or S-acylation is the posttranslational attachment of fatty acids to cysteine residues and is common among integral and peripheral membrane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect,… read more here.

Keywords: protein; palmitoylation; acylation proteins; fatty acids ... See more keywords

Quantitative Analysis of Protein S-Acylation Site Dynamics Using Site-Specific Acyl-Biotin Exchange (ssABE).

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recommendations! Published in 2019 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-9232-4_6

Abstract: Protein S-acylation (palmitoylation) is a reversible lipid modification that is increasingly recognized as an important regulator of protein function, including membrane association, trafficking, and subcellular localization. Most proteomic methods to study palmitoylation allow characterization of… read more here.

Keywords: palmitoylation; protein acylation; site; acyl biotin ... See more keywords

CCN3 secretion is regulated by palmitoylation via ZDHHC22.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.12.128

Abstract: Normal extracellular secretion of nephroblastoma overexpressed (NOV, also known as CCN3) is important for the adhesion, migration, and differentiation of cells. In previous studies, we have shown that the intracellular accumulation of CCN3 inhibits the… read more here.

Keywords: palmitoylation; secretion; zdhhc22; ccn3 secretion ... See more keywords

Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TF

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recommendations! Published in 2019 at "Biochemical and Biophysical Research Communications"

DOI: 10.1016/j.bbrc.2019.04.098

Abstract: Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. Although the protein-protein interactions (PPIs) between nonstructural proteins of CHIKV have been extensively established, the complete CHIKV intraviral interactome remains… read more here.

Keywords: palmitoylation; homo oligomerization; chikv; intraviral interactome ... See more keywords

KChIP2 Serves Multiple Functions in Cardiac Myocytes in Splice Isoform-Dependent Manner

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.230

Abstract: K-channel-interacting-proteins (KChIPs) are EF-hand-motif-bearing Ca sensors that serve diverse functions. KChIP2 is the major KChIP expressed in the heart, that can modulate key cardiac channels (Itof, Nav, CaV and IKur) by directly interacting with their… read more here.

Keywords: kchip2 serves; palmitoylation; kchip2c; kchip2a ... See more keywords