Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01331-22
Abstract: Targeting the cellular sphingolipid metabolism is often discussed as a potential approach to treat associated human diseases such as cancer and Alzheimer's disease. Alternatively, it is also a possible target for the development of antifungal… read more here.
Keywords: polyketide tail; inhibition; serine palmitoyltransferase; palmitoyltransferase ... See more keywords
Palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022019056
Abstract: Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of patients who receive the most intensive treatment inevitably suffer disease relapse, likely resulting from the persistence of drug‑resistant leukemia stem cells (LSCs). AML… read more here.
Keywords: zdhhc21; palmitoyltransferase; aml cells; oxidative phosphorylation ... See more keywords
Serine Palmitoyltransferase (SPT)-related Neurodegenerative and Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuromuscular Diseases"
DOI: 10.3233/jnd-240014
Abstract: Motor neuron diseases and peripheral neuropathies are heterogeneous groups of neurodegenerative disorders that manifest with distinct symptoms due to progressive dysfunction or loss of specific neuronal subpopulations during different stages of development. A few monogenic,… read more here.
Keywords: spt related; palmitoyltransferase; serine palmitoyltransferase; related neurodegenerative ... See more keywords