PAMAM G4.5 dendrimers for targeted delivery of ferulic acid and paclitaxel to overcome P‐glycoprotein‐mediated multidrug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27645
Abstract: In this study, we prepared ferulic acid (FA) and paclitaxel (PTX) co‐loaded polyamidoamine (PAMAM) dendrimers conjugated with arginyl–glycyl–aspartic acid (RGD) to overcome P‐glycoprotein (P‐gp)‐mediated multidrug resistance (MDR). FA was released in greater extent (80%) from… read more here.
Keywords: pamam; ferulic acid; rgd; acid paclitaxel ... See more keywords
Synthesis and evaluation of [177Lu]Lu‐labeled porphyrin loaded PAMAM dendrimer: Impact on tumor uptake and pharmacokinetics
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21996
Abstract: The objective of the present work is to evaluate the ability of the radiolabeled PAMAM dendrimers (polyamidoamine) towards facilitating the delivery of an in‐house synthesized porphyrin derivative in the tumorous lesions to evaluate their candidature… read more here.
Keywords: tumor; pamam; pamam stap; dota pamam ... See more keywords
Preparation and characterization of silicone rubber through the reaction between γ‐chloropropyl and amino groups with siloxane polyamidoamine dendrimers as cross‐linkers
Sign Up to like & getrecommendations! Published in 2018 at "Polymers for Advanced Technologies"
DOI: 10.1002/pat.4204
Abstract: A novel heat-curable silicone rubber (MCSR/Si-PAMAM) was prepared by using siloxane polyamidoamine (Si-PAMAM) dendrimers as cross-linkers and polysiloxane containing γ-chloropropyl groups as gums. The chemical cross-linking occurs through the reaction between Si-PAMAM dendrimers and polysiloxane… read more here.
Keywords: cross linkers; pamam; mcsr pamam; dendrimers cross ... See more keywords
Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.05.017
Abstract: In this study, we developed bio-stimuli-responsive multi-scale hyaluronic acid (HA) nanoparticles encapsulated with polyamidoamine (PAMAM) dendrimers as the subunits. These HA/PAMAM nanoparticles of large scale (197.10±3.00nm) were stable during systematic circulation then enriched at the… read more here.
Keywords: bio stimuli; pamam; stimuli responsive; multi scale ... See more keywords
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2020.08.009
Abstract: Abstract To improve the efficacy of nucleic acid-based therapeutics, e.g., small interfering RNA (siRNA), transfection agents are needed for efficient delivery into cells. Several classes of dendrimers have been found useful as transfection agents for… read more here.
Keywords: tnf; delivery; pamam; sirna ... See more keywords
Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.12.012
Abstract: The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characterising how differences… read more here.
Keywords: antimicrobial efficacy; pamam; poly amidoamine; amidoamine pamam ... See more keywords
Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.05.045
Abstract: Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical… read more here.
Keywords: therapy; delivery; drug; pamam ... See more keywords
A novel mesoporous nanocarrier: Integrating hollow magnetic fibrous silica with PAMAM into a single nanocomposite for enzyme immobilization
Sign Up to like & getrecommendations! Published in 2019 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2019.01.025
Abstract: Abstract A well-designed mesoporous nanocarrier, integrating hollow magnetic fibrous silica with polyamidoamine (PAMAM) (H-MFS/PAMAM), was obtained for the first time to immobilize porcine pancreas lipase (PPL). The H-MFS, based on the light-weight and hollow Fe3O4… read more here.
Keywords: silica; fibrous silica; mesoporous nanocarrier; pamam ... See more keywords
Polyamidoamine dendrimers: Favorable polymeric nanomaterials for lipase activation
Sign Up to like & getrecommendations! Published in 2020 at "Materials today communications"
DOI: 10.1016/j.mtcomm.2020.101492
Abstract: Abstract Dendrimers are highly branched synthetic macromolecules that offer promising prospects for utilizing them in broad applications. This study investigates the role of polyamidoamine (PAMAM) dendrimer for lipase-catalyzed reaction in aqueous solution. The hydrolysis of… read more here.
Keywords: pamam dendrimer; favorable polymeric; polyamidoamine dendrimers; polymeric nanomaterials ... See more keywords
Enzyme immobilized on polyamidoamine-coated magnetic microspheres for α-glucosidase inhibitors screening from Radix Paeoniae Rubra extracts accompanied with molecular modeling.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2018.11.009
Abstract: In this study, a method for direct screening and identification of α-glucosidase inhibitors (AGIs) from extracts of natural products was established based on polyamidoamine (PAMAM) coated magnetic microspheres. A facile route to synthesize the magnetic… read more here.
Keywords: glucosidase inhibitors; enzyme; pamam; radix paeoniae ... See more keywords
Selectively Fluorinated PAMAM-Arginine Conjugates as Gene Delivery Vectors.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00139
Abstract: Polyamidoamine (PAMAM) dendrimers are among the most studied cationic polymers as non-viral gene delivery vectors. However, an "ideal" PAMAM-based gene delivery vector is still missing due to the high manufacturing costs and non-negligible cytotoxicity associated… read more here.
Keywords: delivery vectors; arginine; pamam; gene delivery ... See more keywords