PAMAM G4.5 dendrimers for targeted delivery of ferulic acid and paclitaxel to overcome P‐glycoprotein‐mediated multidrug resistance
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27645
Abstract: In this study, we prepared ferulic acid (FA) and paclitaxel (PTX) co‐loaded polyamidoamine (PAMAM) dendrimers conjugated with arginyl–glycyl–aspartic acid (RGD) to overcome P‐glycoprotein (P‐gp)‐mediated multidrug resistance (MDR). FA was released in greater extent (80%) from… read more here.
Keywords: pamam; ferulic acid; rgd; acid paclitaxel ... See more keywords
Determination of non-traditional intrinsic fluorescence (NTIF) emission sites in 1-(4-carbomethoxypyrrolidone)-PAMAM dendrimers using CNDP-based quenching studies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanoparticle Research"
DOI: 10.1007/s11051-018-4310-7
Abstract: A unique photoluminescent phenomenon producing inexplicable, blue emissions [λEx = 365 nm; λEm = 460 nm] in the absence of traditional aromatic fluorophores has been observed in a variety of surface functionalized poly(amidoamine) (PAMAM) dendrimers over the past two decades. This… read more here.
Keywords: cndp; pamam dendrimers; non traditional; traditional intrinsic ... See more keywords
Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.12.012
Abstract: The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characterising how differences… read more here.
Keywords: antimicrobial efficacy; pamam; poly amidoamine; amidoamine pamam ... See more keywords
Ambient temperature self-crosslinking latices using low generation PAMAM dendrimers as inter-particle crosslinking agents
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Organic Coatings"
DOI: 10.1016/j.porgcoat.2018.02.027
Abstract: Abstract This study focuses on one-component ambient temperature self-crosslinking latex coating compositions containing poly(amidoamine) (PAMAM) dendrimers in the role of eco-friendly crosslinking agents. Low generation amine-terminated PAMAM dendrimers of in the form of aqueous solution… read more here.
Keywords: temperature self; self crosslinking; ambient temperature; pamam dendrimers ... See more keywords
Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c8md00419f
Abstract: Pancreatic β-cell membranes and presynaptic areas of neurons contain analogous protein complexes that control the secretion of bioactive molecules. These complexes include the neuroligins (NLs) and their binding partners, the neurexins (NXs). It has been… read more here.
Keywords: polyamidoamine based; proliferation; pamam; based pamam ... See more keywords
Synthesis of surface-modified TREN-cored PAMAM dendrimers and their effects on the solubility of sulfamethoxazole (SMZ) as an analog antibiotic drug
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2016.1221425
Abstract: Abstract Sulfamethoxazole (SMZ) is a sulfonamide and used widely in the treatment of bacteriostatic and urinary tract infections with trimethoprim as an antibiotic. The problem with SMZ is its poor water solubility, therefore, low bioavailability… read more here.
Keywords: sulfamethoxazole smz; tris; drug; smz ... See more keywords
Reaction of Amino-Terminated PAMAM Dendrimers with Carbon Dioxide in Aqueous and Methanol Solutions
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27020540
Abstract: Polyamines have been used as active materials to capture carbon dioxide gas based on its well-known reaction with amines to form carbamates. This work investigates the reactions between three amino-terminated poly(amidoamine) (PAMAM) dendrimers (G1, G3… read more here.
Keywords: pamam dendrimers; amino terminated; reaction; carbon dioxide ... See more keywords
An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14030655
Abstract: The chemokine receptor 4 (CXCR4) is a promising diagnostic and therapeutic target for the management of various cancers. CXCR4 has been utilized in immunotherapy, targeted drug delivery, and endoradiotherapy. Poly(amidoamine) [PAMAM] dendrimers are well-defined polymers… read more here.
Keywords: targeting pamam; evaluation cxcr4; cxcr4; pamam dendrimer ... See more keywords
Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Study
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020689
Abstract: Cisplatin (cis-diamminedichloroplatinum(II)) is a potent chemotherapeutic agent commonly used to treat cancer. However, its use also leads to serious side effects, such as nephrotoxicity, ototoxicity, and cardiotoxicity, which limit the dose that can be safely… read more here.
Keywords: pamam dendrimers; cell; mono bidentate; cisplatin ... See more keywords
Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051515
Abstract: Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment. Platinum(IV) complexes were linked to terminal NH2… read more here.
Keywords: pamam dendrimers; platinum complexes; spectroscopy; delivery properties ... See more keywords