Phase 1b study of pan‐AKT inhibitor vevorisertib alone or with paclitaxel or fulvestrant in PIK3CA/AKT/PTEN‐mutated advanced solid tumors
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DOI: 10.1002/cncr.34733
Abstract: In this first‐in‐human phase 1b study (ClinicalTrials.gov identifier NCT02761694) of advanced solid tumors with PIK3CA/AKT/PTEN mutations, the authors investigated the safety and efficacy of the pan‐AKT inhibitor vevorisertib (MK‐4440; ARQ 751) as monotherapy or with… read more here.
Keywords: pan akt; pik3ca akt; solid tumors; phase study ... See more keywords
Combination treatment of cancer cells with pan-Akt and pan-mTOR inhibitors: effects on cell cycle distribution, p-Akt expression level and radiolabelled-choline incorporation
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DOI: 10.1007/s10637-018-0642-5
Abstract: SummarySignal transduction pathways, which regulate cell growth and survival, are up-regulated in many cancers and there is considerable interest in their pharmaceutical modulation for cancer treatment. However inhibitors of single pathway components induce feedback mechanisms… read more here.
Keywords: pan mtor; treatment; pan akt; cancer cells ... See more keywords
Alterations in the insulin signaling pathway in bovine ovaries with experimentally induced follicular persistence.
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DOI: 10.1016/j.theriogenology.2020.09.016
Abstract: Reproductive diseases in dairy cows as cystic ovarian disease (COD) represent a major problem that impacts on dairy production. COD is characterized by anovulation, persistence of the dominant follicle, and interruption of normal estrous cycles.… read more here.
Keywords: follicular persistence; pan akt; signaling pathway; persistence ... See more keywords
Lactic acidosis induces resistance to the pan-Akt inhibitor uprosertib in colon cancer cells
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DOI: 10.1038/s41416-020-0777-y
Abstract: Background Akt signalling regulates glycolysis and drives the Warburg effect in cancer, thus decreased glucose utilisation is a pharmacodynamic marker of Akt inhibition. However, cancer cells can utilise alternative nutrients to glucose for energy such… read more here.
Keywords: lactic acidosis; pan akt; resistance; cancer cells ... See more keywords
Molecular target: pan-AKT in gastric cancer
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DOI: 10.1136/esmoopen-2020-000728
Abstract: The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in multiple cellular processes, including cell survival, proliferation, differentiation, metabolism and cytoskeletal reorganisation. The downstream effectors of this PI3K pathway… read more here.
Keywords: gastric cancer; molecular target; target; pan akt ... See more keywords