Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13324
Abstract: Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging… read more here.
Keywords: telomerase; telomerase activity; genomic epigenomic; pan cancer ... See more keywords
Transcriptomic pan‐cancer analysis using rank‐based Bayesian inference
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13354
Abstract: The analysis of whole genomes of pan‐cancer data sets provides a challenge for researchers, and we contribute to the literature concerning the identification of robust subgroups with clear biological interpretation. Specifically, we tackle this unsupervised… read more here.
Keywords: pan cancer; analysis; based bayesian; rank based ... See more keywords
Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan‐cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3375
Abstract: The pan‐cancer analysis has recently brought us into a novel level of cancer research. Nowadays, the Circular RNAs (circRNAs) is becoming increasingly important in the occurrence and progression of tumors. Nevertheless, the specific expression patterns… read more here.
Keywords: pan cancer; circular rnas; bioinformatics analysis; screening bioinformatics ... See more keywords
Pan-cancer analysis of GALNTs expression identifies a prognostic of GALNTs feature in low grade glioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.5ma1221-468r
Abstract: Polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts), a group of isoenzymes that initiate mucin-type O-glycosylation, have been shown to mediate tumor growth and metastasis in various cancer types. However, data on the clinical significance and features of GalNAc-Ts remain… read more here.
Keywords: expression; low grade; cancer; tumor ... See more keywords
Integrating Protein-Protein Interaction Networks and Somatic Mutation Data to Detect Driver Modules in Pan-Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Interdisciplinary sciences, computational life sciences"
DOI: 10.1007/s12539-021-00475-y
Abstract: With the constant update of large-scale sequencing data and the continuous improvement of cancer genomics data, such as International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), it gains increasing importance to detect… read more here.
Keywords: pan cancer; driver modules; interaction; cancer ... See more keywords
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.09.001
Abstract: We characterized the landscape and drug sensitivity of ERBB2 (HER2) mutations in cancers. In 11 datasets (n = 211,726), ERBB2 mutational hotspots varied across 25 tumor types. Common HER2 mutants yielded differential sensitivities to eleven EGFR/HER2… read more here.
Keywords: pan cancer; dm1; cancer landscape; cancer ... See more keywords
Charting a Course to a Cure
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.048
Abstract: In this issue ofCell and in papers appearing inCell Reports,Cancer Cell,Cell Systems, and Immunity, we are proud to present the Pan-Cancer Atlas. The Pan-Cancer Atlas is the culmination of more than a decade of work… read more here.
Keywords: pan cancer; medicine; cancer atlas; cancer ... See more keywords
A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.08.018
Abstract: Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting that the choice of promoter is as important as its level of transcriptional activity. However, while a global change in transcription is recognized as… read more here.
Keywords: pan cancer; transcriptome analysis; cancer transcriptome; cancer ... See more keywords
A pan-cancer organoid platform for precision medicine.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109429
Abstract: Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However, utilizing TOs for systems-biology-based approaches has been limited by a lack of scalable and reproducible… read more here.
Keywords: medicine; pan cancer; precision medicine; platform ... See more keywords
Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109873
Abstract: Long non-coding RNAs (lncRNAs) are increasingly recognized as functional units in cancer and powerful biomarkers; however, most remain uncharacterized. Here, we analyze 5,592 prognostic lncRNAs in 9,446 cancers of 30 types using machine learning. We… read more here.
Keywords: pan cancer; gliomas; hoxa10; non coding ... See more keywords
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.08.010
Abstract: We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode… read more here.
Keywords: analysis reveals; tgf superfamily; pan cancer; cancer analysis ... See more keywords