Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13324
Abstract: Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging… read more here.
Keywords: telomerase; telomerase activity; genomic epigenomic; pan cancer ... See more keywords
Transcriptomic pan‐cancer analysis using rank‐based Bayesian inference
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13354
Abstract: The analysis of whole genomes of pan‐cancer data sets provides a challenge for researchers, and we contribute to the literature concerning the identification of robust subgroups with clear biological interpretation. Specifically, we tackle this unsupervised… read more here.
Keywords: pan cancer; analysis; based bayesian; rank based ... See more keywords
Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan‐cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3375
Abstract: The pan‐cancer analysis has recently brought us into a novel level of cancer research. Nowadays, the Circular RNAs (circRNAs) is becoming increasingly important in the occurrence and progression of tumors. Nevertheless, the specific expression patterns… read more here.
Keywords: pan cancer; circular rnas; bioinformatics analysis; screening bioinformatics ... See more keywords
Pan‐Cancer Single‐Cell Transcriptomic Analysis Reveals Divergent Expression of Embryonic Proangiogenesis Gene Modules in Tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70373
Abstract: Angiogenesis is indispensable for the sustained survival and progression of both embryonic development and tumorigenesis. This intricate process is tightly regulated by a multitude of pro‐angiogenic genes. The presence of gene modules facilitating angiogenesis has… read more here.
Keywords: cancer single; gene modules; pan cancer; gene ... See more keywords
Pan-cancer analysis of GALNTs expression identifies a prognostic of GALNTs feature in low grade glioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.5ma1221-468r
Abstract: Polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts), a group of isoenzymes that initiate mucin-type O-glycosylation, have been shown to mediate tumor growth and metastasis in various cancer types. However, data on the clinical significance and features of GalNAc-Ts remain… read more here.
Keywords: expression; low grade; cancer; tumor ... See more keywords
LINC00152: Potential driver oncogene in pan‐cancer
Sign Up to like & getrecommendations! Published in 2024 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1851
Abstract: Long noncoding RNAs (lncRNA) are a class of non‐coding RNAs greater than 200 bp in length with limited peptide‐coding function. The transcription of LINC00152 is derived from chromosome 2p11.2. Many studies prove that LINC00152 influences the… read more here.
Keywords: pan cancer; driver oncogene;
A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05640-6
Abstract: There is currently a limited number of studies on transglutaminase type 1 (TGM1) in tumors. The objective of this study is to perform a comprehensive analysis across various types of cancer to determine the prognostic… read more here.
Keywords: cancer; tgm1; analysis; pan cancer ... See more keywords
Pan-cancer and multi-omics analysis: NDUFA1 is a potential therapeutic target and prognostic marker for esophageal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-025-09993-7
Abstract: The study examined the NDUFA1 expression and its prognostic value in pan-cancer, especially in esophageal cancer (ESCA). Its carcinogenic effect on ESCA was further elucidated. TCGA database was used to examine NDUFA1 expression and its… read more here.
Keywords: ndufa1 knockdown; cancer; esca; cell ... See more keywords
Integrating Protein-Protein Interaction Networks and Somatic Mutation Data to Detect Driver Modules in Pan-Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Interdisciplinary sciences, computational life sciences"
DOI: 10.1007/s12539-021-00475-y
Abstract: With the constant update of large-scale sequencing data and the continuous improvement of cancer genomics data, such as International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), it gains increasing importance to detect… read more here.
Keywords: pan cancer; driver modules; interaction; cancer ... See more keywords
Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.09.001
Abstract: We characterized the landscape and drug sensitivity of ERBB2 (HER2) mutations in cancers. In 11 datasets (n = 211,726), ERBB2 mutational hotspots varied across 25 tumor types. Common HER2 mutants yielded differential sensitivities to eleven EGFR/HER2… read more here.
Keywords: pan cancer; dm1; cancer landscape; cancer ... See more keywords
Charting a Course to a Cure
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.048
Abstract: In this issue ofCell and in papers appearing inCell Reports,Cancer Cell,Cell Systems, and Immunity, we are proud to present the Pan-Cancer Atlas. The Pan-Cancer Atlas is the culmination of more than a decade of work… read more here.
Keywords: pan cancer; medicine; cancer atlas; cancer ... See more keywords