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Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28143
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of the currently ongoing coronavirus disease 2019 (COVID‐19) pandemic, has posed a serious threat to global public health. Recently, several SARS‐CoV‐2 variants of concern (VOCs)…
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Keywords:
pan coronavirus;
coronavirus fusion;
coronavirus;
fusion inhibitors ... See more keywords
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Published in 2021 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2021.03.024
Abstract: Coronaviruses have caused multiple epidemics in the past two decades, in addition to the current COVID-19 pandemic that is severely damaging global health and the economy. Coronaviruses employ between twenty and thirty proteins to carry…
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Keywords:
activation mechanism;
pan coronavirus;
pocket;
cryptic pocket ... See more keywords
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Published in 2021 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2021.113814
Abstract: Indomethacin (INM), a well-known non-steroidal anti-inflammatory drug, has recently gained attention for its antiviral activity demonstrated in drug repurposing studies against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Although the mechanism of action of INM is…
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Keywords:
based protacs;
pan coronavirus;
inm;
protacs ... See more keywords
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Published in 2023 at "Viruses"
DOI: 10.3390/v15041001
Abstract: The unprecedented pandemic of COVID-19, caused by a novel coronavirus, SARS-CoV-2, has led to massive human suffering, death, and economic devastation worldwide. The virus is mutating fast to more transmissible and infectious variants. The Delta…
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Keywords:
pan coronavirus;
highly potent;
coronavirus;
potent small ... See more keywords
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Published in 2022 at "Future Medicinal Chemistry"
DOI: 10.4155/fmc-2021-0311
Abstract: Background: In the last two decades, the world has witnessed the emergence of zoonotic corona viruses (CoVs), which cause mild to severe respiratory diseases in humans. Human coronaviruses (HCoVs), mainly from the alpha-CoV and beta-CoV…
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Keywords:
pan coronavirus;
cov;
dyphylline pan;
dyphylline ... See more keywords