A pan-genotype hepatitis C virus viral vector vaccine generates T-cells and neutralizing antibodies in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32470
Abstract: BACKGROUND & AIMS A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization (WHO) elimination targets. Neutralizing antibodies (nAb), CD4+ and CD8+ T-cells are associated with spontaneous clearance of… read more here.
Keywords: viral vector; pan genotype; hcv; neutralizing antibodies ... See more keywords
Design, synthesis and identification of silicon-containing HCV NS5A inhibitors with pan-genotype activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.025
Abstract: Modification of a HCV NS5A inhibitor, ombitasvir, led to the identification of 10d with improved pan-genotype NS5A inhibition and better pharmacokinetic properties. The key structural changes to ombitasvir include bioisosteric replacement of carbon with silicon… read more here.
Keywords: pan genotype; hcv; silicon containing; hcv ns5a ... See more keywords