Articles with "pan jak" as a keyword



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Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.

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Published in 2017 at "ACS chemical biology"

DOI: 10.1021/acschembio.7b00116

Abstract: PF-956980 has been used previously as a JAK3-selective chemical probe in numerous cell-based experiments. Here, we report that not only is PF-956980 a pan-JAK ATP-competitive inhibitor but it also causes selective reduction of endogenous JAK2… read more here.

Keywords: atp competitive; jak2 jak3; pan jak; jak2 ... See more keywords