Pan-neuronal knockdown of Ras GTPase-activating protein 1 alters Drosophila activity and sleep behavior.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.22001
Abstract: Ras signaling pathways are involved in numerous cellular functions and, for this reason, are highly regulated. In addition to alterations in the Ras proteins themselves, defects in Ras regulatory proteins, such as GTPase-activating proteins (GAPs)… read more here.
Keywords: behavior; gtpase activating; physiology; activity ... See more keywords
Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01073-7
Abstract: The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its ability to phosphorylate the proteins tau… read more here.
Keywords: severe cerebellar; pan neuronal; neurodegeneration; expression ... See more keywords