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Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold.

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0 Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.02.032

Abstract: Herein, we present the design and synthesis of 2(1H)-pyrazinone based HCV NS3 protease inhibitors and show that elongated R3 urea substituents were associated with increased inhibitory potencies over several NS3 protein variants. The inhibitors are… read more here.

Keywords: inhibitors hepatitis; ns3 protease; pyrazinone; pan ns3 ... See more keywords