Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.04.025
Abstract: BACKGROUND AND AIMS Peroxisome proliferator-activated receptors (PPARs) are essential regulators of whole-body metabolism, but also modulate inflammation in immune cells, notably macrophages. We compared selective PPAR agonists with the pan-PPAR agonist lanifibranor as therapeutic agents… read more here.
Keywords: ppar; ppar agonists; hepatic macrophages; pan ppar ... See more keywords
Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283743
Abstract: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, and their activation has been proven to treat mild liver fibrosis, reduce steatosis, inflammation, and the extrahepatic effects of chronic liver disease. Considering the significance of the PPARs,… read more here.
Keywords: dynamics domain; ppar; deciphering relational; relational dynamics ... See more keywords