Pleural metastasis from parotid secretory carcinoma: First report of morphology on effusion cytology, and role of pan‐TRK immunohistochemistry
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25057
Abstract: Distant metastasis from salivary gland secretory carcinoma (SC) is rare, with lung and pleura being the most frequent site. While cytological features of SC on fine needle aspirates are well documented, its morphology in serous… read more here.
Keywords: immunohistochemistry; secretory carcinoma; effusion cytology; pan trk ... See more keywords
S100 and Pan-Trk Staining to Report NTRK Fusion-Positive Uterine Sarcoma: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual Meeting.
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000702
Abstract: NTRK fusion-positive uterine sarcoma is a recently recognized mesenchymal tumor that is defined by its morphologic resemblance to soft tissue fibrosarcoma, NTRK gene rearrangements, and potential response to Trk inhibition. Reported lesions affect premenopausal women… read more here.
Keywords: fusion positive; uterine sarcoma; pan trk; fusion ... See more keywords
Demonstration of an anti‐hyperalgesic effect of a novel pan‐Trk inhibitor PF‐06273340 in a battery of human evoked pain models
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13448
Abstract: AIM Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small… read more here.
Keywords: pan trk; trk inhibitor; inhibitor; primary endpoints ... See more keywords
Evaluation of pan‐TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis‐like neural tumour and histological mimics
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13666
Abstract: Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and ETV6–NTRK3 gene fusion in most cases. Given histological overlap with other spindle‐cell tumours, the diagnosis can be challenging and often requires molecular confirmation. A… read more here.
Keywords: pan trk; trk immunohistochemistry; immunohistochemistry infantile; infantile fibrosarcoma ... See more keywords
Diagnostic utility of pan‐Trk immunohistochemistry for inflammatory myofibroblastic tumours
Sign Up to like & getrecommendations! Published in 2019 at "Histopathology"
DOI: 10.1111/his.14010
Abstract: Inflammatory myofibroblastic tumour (IMT) is a spindle cell neoplasm of intermediate malignancy, and the diagnosis is often challenging due to the morphological overlap with other spindle cell neoplasms and reactive lesions. More than half of… read more here.
Keywords: pan trk; trk immunohistochemistry; utility pan; diagnostic utility ... See more keywords
The Diagnostic Value of Pan-Trk Expression to Detect Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion in CNS Tumours: A Study Using Next-Generation Sequencing Platform
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610233
Abstract: Background: Neurotrophic tyrosine receptor kinase (NTRK) fusion has been detected in rare types of CNS tumours, which can promote tumorigenesis. The efficacy of Trk inhibitor became a significant therapeutic interest. Our aim was to investigate… read more here.
Keywords: cns tumours; fusion; pan; pan trk ... See more keywords
NTRK Fusions in 1113 Solid Tumors in a Single Institution
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12061450
Abstract: Simple Summary Recently, there has been increasing interest in identifying NTRK fusions in various tumors, as they are therapeutically targetable driver mutations. In tumor types with low-frequency NTRK fusions, recent recommendations on NTRK testing recommend… read more here.
Keywords: trk expression; ntrk fusions; pan trk; 1113 solid ... See more keywords
Limited Accuracy of Pan-Trk Immunohistochemistry Screening for NTRK Rearrangements in Follicular-Derived Thyroid Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137470
Abstract: Patients with advanced thyroid cancer harboring NTRK rearrangements can be treated with highly effective selective inhibitors. Immunohistochemistry (IHC) analysis, to detect Trk protein expression, represents an appealing screening strategy for NTRK rearrangements, but its efficacy… read more here.
Keywords: ntrk rearrangements; derived thyroid; thyroid cancer; sensitivity specificity ... See more keywords