Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.
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DOI: 10.3892/ijo.2016.3792
Abstract: MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro a resistance model… read more here.
Keywords: vegfr inhibition; pan vegfr; using cabozantinib; inhibition ... See more keywords