Bitter apricot ethanolic extract induces apoptosis through increasing expression of Bax/Bcl-2 ratio and caspase-3 in PANC-1 pancreatic cancer cells
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DOI: 10.1007/s11033-020-05286-w
Abstract: Pancreatic cancer is the fourth common cause of cancer death. Surgery and chemotherapy are the common treatment strategies for pancreatic cancer patients; however, the response rate is less than 20% at advanced stages. In recent… read more here.
Keywords: ethanolic extract; pancreatic cancer; panc; cancer ... See more keywords
Périartérite noueuse cutanée du sujet jeune : penser à la génétique
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DOI: 10.1016/j.annder.2017.09.405
Abstract: Introduction Des mutations du gene CERC1, responsables d’un deficit en adenosine deaminase 2 (ADA2), sont rapportees dans des cas familiaux de periarterite noueuse cutanee (PANc) a debut precoce. Nous rapportons un cas de PANc d’origine… read more here.
Keywords: recherche; sujet jeune; mutation; panc ... See more keywords
Core–shell structural PANI-derived carbon@Co–Ni LDH electrode for high-performance asymmetric supercapacitors
Sign Up to like & getrecommendations! Published in 2018 at "Sustainable Energy and Fuels"
DOI: 10.1039/c8se00123e
Abstract: Carbon/metal nanocomposites have been considered promising electrode materials for application in supercapacitors owing to their combination of good electrical conductivity, excellent cycle stabilities of the electronic double layer capacitor (EDLC) and high specific capacitance of… read more here.
Keywords: core shell; carbon; derived carbon; panc ... See more keywords
Immunogenicity and cytotoxicity of a platinum(IV) complex derived from capsaicin.
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DOI: 10.1039/d0dt03470c
Abstract: Platinum-based anticancer drugs constitute the cornerstone of chemotherapy for various cancers. Although cytotoxic agents are considered to have immunosuppressive effects, increasing evidence suggests that some cytotoxic compounds can effectively stimulate the antitumor immune response by… read more here.
Keywords: platinum; cancer cells; panc; cytotoxicity ... See more keywords
Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2019.1585820
Abstract: Abstract The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25–150 μM) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was… read more here.
Keywords: panc cells; pancreatic cancer; metastasis; human pancreatic ... See more keywords
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14017
Abstract: Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high‐ and low‐penetrance genes have been implicated in PanC, their roles… read more here.
Keywords: risk; genetic variants; pathway genes; panc ... See more keywords
Abstract 5112: Evaluation of FF-10502-01, a new pyrimidine nucleoside analogue, in pancreatic (PANC) patient-derived xenograft (PDX) models compared to gemcitabine and in combination with nab-paclitaxel
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5112
Abstract: Introduction FF-10502-01 is a synthetic pyrimidine nucleoside analogue structurally similar to gem with a substitution of sulfur for oxygen in the pentose sugar. In previous studies, FF-10502-01 demonstrated preclinical efficacy across multiple solid tumors, including… read more here.
Keywords: combination; gem; pdx models; nab pac ... See more keywords
Abstract 1047: Plasma KRAS mutations as predictive biomarkers for pancreatic cancer in high-risk group
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1047
Abstract: Pancreatic cancer (PANC) has among solid malignancies one of the lowest 5-years survival rates - less than 10%. To improve the prognosis of PANC, it is necessary to develop tools that will enable earlier diagnosis.… read more here.
Keywords: risk group; panc; kras mutations; cancer ... See more keywords
Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs)
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DOI: 10.1371/journal.pone.0184110
Abstract: Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates. The presence of cancer stem-like cells (CSCs) is believed to be among the underlying reasons for the aggressiveness of PDAC, which contributes… read more here.
Keywords: gemcitabine; gemcitabine treatment; mutant p53; panc ... See more keywords
Mechanism of metformin enhancing the sensitivity of human pancreatic cancer cells to gem-citabine by regulating the PI3K/Akt/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201912_19666
Abstract: OBJECTIVE To investigate the effect of metformin (MET) on enhancing the sensitivity of human pancreatic cancer cells to gemcitabine (GEM) by regulating the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. MATERIALS… read more here.
Keywords: gem; cell lines; panc gem; mtor ... See more keywords
Metformin reduces pancreatic cancer cell proliferation and increases apoptosis through MTOR signaling pathway and its dose-effect relationship.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202005_21316
Abstract: OBJECTIVE To study the influences of metformin on the proliferation and apoptosis of pancreatic cancer cells and its dose-effect relationship and crucial molecular mechanism. MATERIALS AND METHODS With human pancreatic cancer cell line PANC-1 as… read more here.
Keywords: apoptosis; panc cells; pancreatic cancer; proliferation ... See more keywords