Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22561
Abstract: Perfluoroalkyl substances, such as perfluorooctanoic acid (PFOA), are widely used in consumer and industrial applications. Human epidemiologic and animal studies suggest that PFOA exposure elicits adverse effects on the pancreas; however, little is known about… read more here.
Keywords: perfluorooctanoic acid; pancreatic acinar; pfoa; unfolded protein ... See more keywords
Defining the role of systemic therapy in resectable pancreatic acinar cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26785
Abstract: Following resection of pancreatic acinar cell carcinoma (PACC) distant recurrence remains high. We utilized the national cancer database (NCDB) to evaluate the role of systemic therapy in early‐stage resected PACC. read more here.
Keywords: cell carcinoma; role systemic; pancreatic acinar; acinar cell ... See more keywords
Development of Pancreatic Acinar Cell Metaplasia During Gastric Repair in a Rat Duodenal Contents Reflux Model
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06342-y
Abstract: Background We previously reported the development of pancreatic acinar cell metaplasia (PACM) in the glandular stomach of a duodenal contents reflux model (reflux model). Aims We aimed to investigate the characteristics and histogenesis of PACM… read more here.
Keywords: pancreatic acinar; contents reflux; model; acinar cell ... See more keywords
Undercarboxylated osteocalcin downregulates pancreatic lipase expression in an ATF4-dependent manner in pancreatic acinar cells.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.06.009
Abstract: Osteocalcin is an osteoblast-specific secreted protein that has been associated with endocrine roles in multiple aspects of energy metabolism. We examined whether undercarboxylated osteocalcin (ucOC) downregulates pancreatic lipase (PNLIP) expression in pancreatic acinar cells and… read more here.
Keywords: pancreatic acinar; pnlip expression; expression; acinar cells ... See more keywords
The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2020.10.062
Abstract: Highlights • Pancreatic acinar cell carcinoma (ACC) may present with pancreatic panniculitis.• Complete surgical resection of ACC can successfully treat pancreatic panniculitis.• Aggressive surgery for ACC can lead to prolonged disease-free survival. read more here.
Keywords: pancreatic acinar; panniculitis; cell carcinoma; pancreatic panniculitis ... See more keywords
Lipase hypersecretion syndrome: A distinct form of paraneoplastic syndrome specific to pancreatic acinar carcinomas.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2019.07.001
Abstract: Lipase hypersecretion syndrome (LHS) is a paraneoplastic syndrome seen exclusively as a result of pancreatic acinar cell carcinoma (ACC). In LHS, acinar enzymes (lipase, trypsin and chymotrypsin) which are normally secreted to the duodenum for… read more here.
Keywords: hypersecretion syndrome; pancreatic acinar; lipase hypersecretion; paraneoplastic syndrome ... See more keywords
Mitogen-activated protein kinase-interacting kinase 1 is involved in mTOR-mediated pancreatic exocrine function of bovine pancreatic acinar cells with leucine supply.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of animal nutrition"
DOI: 10.1080/1745039x.2023.2199839
Abstract: ABSTRACT Leucine improves the exocrine capacity of the cow pancreas, but the mechanism was not revealed clearly. Mitogen-activated protein kinase-interacting kinase 1 (MNK1) is a pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme… read more here.
Keywords: mnk1; exocrine function; kinase; pancreatic exocrine ... See more keywords
Effects of tRNA-derived fragments and microRNAs regulatory network on pancreatic acinar intracellular trypsinogen activation
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018880
Abstract: ABSTRACT Acute pancreatitis (AP) is a common gastrointestinal disease with substantial morbidity and mortality. Pancreatic acinar intracellular trypsinogen activation (PAITA) is an important event in the early stage of AP. The present study aimed to… read more here.
Keywords: trypsinogen; acinar intracellular; pancreatic acinar; trypsinogen activation ... See more keywords
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000013113
Abstract: Rationale: Pancreatic acinar cell carcinoma (PACC) is a relatively rare malignancy of the exocrine pancreas. BRCA2, a cancer susceptibility gene, has been widely studied in breast and ovarian carcinomas as mutation carriers for this gene… read more here.
Keywords: pancreatic acinar; cell carcinoma; germline brca2; acinar cell ... See more keywords
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.12505
Abstract: Given the rarity of the disease, the post‐resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we aimed to analyze the outcomes of patients with localized pancreatic ACC who underwent… read more here.
Keywords: cell carcinoma; acinar cell; pancreatic acinar; outcomes patients ... See more keywords
Pancreatic acinar cell carcinoma with pleomorphic and spindle cells: An autopsy-proven case.
Sign Up to like & getrecommendations! Published in 2023 at "Pathology international"
DOI: 10.1111/pin.13326
Abstract: Pancreatic acinar cell carcinomas are glandular and have amphophilic/eosinophilic cytoplasm, presenting acinar, solid, and trabecular structures. Unusual histological features of acinar cell carcinoma are known, such as oncocytic, pleomorphic, spindle, and clear cell variants, but… read more here.
Keywords: pleomorphic spindle; cell; cell carcinoma; spindle cells ... See more keywords