Apoptotic susceptibility of pancreatic alpha cells to environmentally relevant dose levels of bisphenol‐A versus dibutyl phthalate is mediated by HSP60/caspase‐3 expression in male albino rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11909
Abstract: Unfortunately, humanity is exposed to mixed plasticizers such as bisphenol‐A (BPA) and dibutyl phthalate (DBP) that are leached from the daily used plastic products. Previous studies have demonstrated their potential in pancreatic beta cell injury… read more here.
Keywords: pancreatic alpha; dibutyl phthalate; hsp60 caspase; expression ... See more keywords
Antioxidant effects of epigallocatechin-3-gallate on the aTC1-6 pancreatic alpha cell line.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.006
Abstract: Hypoglycemia is a major barrier to achieving stable metabolic control in patients with diabetes which is a serious clinical concern. With progression of diabetes, the ability of pancreatic α-cells which respond to hypoglycemia becomes impaired;… read more here.
Keywords: pancreatic alpha; oxidative stress; cell; epigallocatechin gallate ... See more keywords
EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1134478
Abstract: Introduction Beta cell dysfunction by loss of beta cell identity, dedifferentiation, and the presence of polyhormonal cells are main characteristics of diabetes. The straightforward strategy for curing diabetes implies reestablishment of pancreatic beta cell function… read more here.
Keywords: cell; pancreatic alpha; arx gene; gene ... See more keywords
Modeling the Amino Acid Effect on Glucagon Secretion from Pancreatic Alpha Cells
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DOI: 10.3390/metabo12040348
Abstract: Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal… read more here.
Keywords: pancreatic alpha; alpha cells; secretion; amino acid ... See more keywords
Extracts of Fruits and Plants Cultivated In Vitro of Aristotelia chilensis (Mol.) Stuntz Show Inhibitory Activity of Aldose Reductase and Pancreatic Alpha-Amylase Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11202772
Abstract: Aristotelia chilensis is a plant whose fruit is considered a powerful natural antioxidant. During the last years, some investigations of the fruit have been carried out, finding antioxidant properties in the juice or the phenolic… read more here.
Keywords: chilensis; inhibition; pancreatic alpha; alpha amylase ... See more keywords