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   Articles with "pancreatic beta" as a keyword



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Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus

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recommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"

DOI: 10.1002/jcla.24454

Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in… read more here.

Keywords: parameters pancreatic; prediabetes type; insulin resistance; cell function ... See more keywords
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Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity

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recommendations! Published in 2020 at "Diabetologia"

DOI: 10.1007/s00125-020-05205-5

Abstract: All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in type 2 diabetes. Deeper understanding of the coupling mechanisms… read more here.

Keywords: beta cells; metabolism; beta; pancreatic beta ... See more keywords
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Caulerpa lentillifera inhibits protein-tyrosine phosphatase 1B and protects pancreatic beta cell via its insulin mimetic effect

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recommendations! Published in 2017 at "Food Science and Biotechnology"

DOI: 10.1007/s10068-017-0068-4

Abstract: The aim of this study was to determine whether Caulerpa lentillifea extract (CLE) can protect pancreatic beta cells and enhance insulin signaling in adipocytes. We measured the protein tyrosine phosphatase (PTP)-1B inhibitory effect of CLE… read more here.

Keywords: insulin; effect; pancreatic beta; cle ... See more keywords
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Alkaline pH induces IRR-mediated phosphorylation of IRS-1 and actin cytoskeleton remodeling in a pancreatic beta cell line.

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recommendations! Published in 2017 at "Biochimie"

DOI: 10.1016/j.biochi.2017.04.002

Abstract: Secretion of mildly alkaline (pH 8.0-8.5) juice to intestines is one of the key functions of the pancreas. Recent reports indicate that the pancreatic duct system containing the alkaline juice may adjoin the endocrine cells… read more here.

Keywords: insulin; actin cytoskeleton; cell line; cytoskeleton remodeling ... See more keywords
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Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function.

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recommendations! Published in 2020 at "Cytokine"

DOI: 10.1016/j.cyto.2020.155147

Abstract: Interferons (IFN) have been shown to alter lipid metabolism in immune and some non-hematopoietic cells and this affects host cell response to pathogens. In type 1 diabetes, IFNγ acts as a proinflammatory cytokine that, along… read more here.

Keywords: beta; pancreatic beta; beta cell; cell ... See more keywords
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Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells

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recommendations! Published in 2019 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2018.09.009

Abstract: Although there is growing evidence that cortistatin regulates several functions in different tissues, its role in the endocrine pancreas is not totally known. Here, we aim to study the effect of cortistatin on pancreatic beta-cells… read more here.

Keywords: beta cells; insulin secretion; beta; pancreatic beta ... See more keywords
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The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification

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recommendations! Published in 2019 at "Communications Biology"

DOI: 10.1038/s42003-019-0351-4

Abstract: Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored.… read more here.

Keywords: pancreatic beta; beta cell; subunit; cell ... See more keywords
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PANCREATIC BETA CELLS COMMUNICATE WITH VAGAL SENSORY NEURONS.

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recommendations! Published in 2020 at "Gastroenterology"

DOI: 10.1053/j.gastro.2020.10.034

Abstract: BACKGROUND AND AIMS Destroying visceral sensory nerves impacts pancreatic islet function, glucose metabolism and diabetes onset, but how islet endocrine cells interact with sensory neurons has not been studied. METHODS We characterized the anatomical pattern… read more here.

Keywords: beta cells; serotonin; beta; pancreatic beta ... See more keywords
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PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2206923119

Abstract: Significance The incidence of type 1 and type 2 diabetes is increasing worldwide. Senescence in pancreatic beta cells is a major contributor to diabetes development. New treatments for cellular senescence are needed to prevent diabetes… read more here.

Keywords: beta; pahsas reduce; pancreatic beta; senescence ... See more keywords
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Elevated androgen levels induce hyperinsulinemia through increase in Ins1 transcription in pancreatic beta cells in female rats†

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recommendations! Published in 2018 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioy017

Abstract: Abstract Hyperandrogenism is associated with hyperinsulinemia and insulin resistance in adult females. We tested whether androgens dysregulate pancreatic beta cell function to induce hyperinsulinemia through transcriptional regulation of insulin gene (Ins) in the islets. Adult… read more here.

Keywords: transcription; androgen; dht; beta ... See more keywords
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The plant product quinic acid activates Ca2+‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

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recommendations! Published in 2019 at "British Journal of Pharmacology"

DOI: 10.1111/bph.14757

Abstract: Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta‐cell functions, which contribute to the control of… read more here.

Keywords: plant; quinic acid; beta; pancreatic beta ... See more keywords