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   Articles with "pancreatic cancer" as a keyword



Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2021.45515

Abstract: Key Points Question What are the comparative short-term and long-term outcomes associated with first-line chemotherapy regimens for patients with metastatic pancreatic cancer, and how do they compare with chemotherapy regimens recommended in Japanese guidelines? Findings… read more here.

Keywords: metastatic pancreatic; pancreatic cancer; first line; line chemotherapy ... See more keywords

Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer

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recommendations! Published in 2024 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.40047

Abstract: This cohort study analyzes associations of body composition variables with metabolites and survival outcomes among patients with metastatic pancreatic cancer. read more here.

Keywords: patients metastatic; metastatic pancreatic; pancreatic cancer; morphomics survival ... See more keywords

Pancreatic Ductal Adenocarcinoma After Hepatitis C Infection

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recommendations! Published in 2025 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2025.43701

Abstract: Key Points Question Is there an association between chronic hepatitis C virus (HCV) infection and pancreatic cancer, independent of other risk factors? Findings In this cohort study of 6.3 million veterans, individuals with chronic HCV… read more here.

Keywords: risk; hepatitis; hcv; infection ... See more keywords
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Evaluation of Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX Treatment.

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recommendations! Published in 2020 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2020.3537

Abstract: Importance The benefit of adjuvant chemotherapy after resection of pancreatic cancer following neoadjuvant combination treatment with folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) is unclear. Objective To assess the association of adjuvant chemotherapy with overall… read more here.

Keywords: chemotherapy; adjuvant chemotherapy; treatment; pancreatic cancer ... See more keywords

Consensus Statement on Mandatory Measurements for Pancreatic Cancer Trials for Patients With Resectable or Borderline Resectable Disease (COMM-PACT-RB): A Systematic Review and Delphi Consensus Statement.

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recommendations! Published in 2022 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2022.0168

Abstract: Importance Pancreatic cancer is the third most common cause of cancer death; however, randomized clinical trials (RCTs) of survival in patients with resectable pancreatic cancer lack mandatory measures for reporting baseline and prognostic factors, which… read more here.

Keywords: prognostic factors; consensus; resectable borderline; pancreatic cancer ... See more keywords

The glycoprotein mucin‐1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer

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recommendations! Published in 2019 at "FEBS Letters"

DOI: 10.1002/1873-3468.13532

Abstract: Aberrant expression of the glycoprotein mucin‐1 (MUC1) has been associated with pancreatic cancer progression and metastasis as a result of mediating the oncogenic transcriptional regulation of target genes. In the present study, we demonstrate that… read more here.

Keywords: glycoprotein mucin; mucin negatively; negatively regulates; pancreatic cancer ... See more keywords

Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12443

Abstract: Forkhead box transcription factor M1 (FOXM1) is a proliferation‐associated transcription factor involved in tumorigenesis through transcriptional regulation of its target genes in various cells, including dendritic cells (DCs). Although previous work has shown that FOXM1… read more here.

Keywords: foxm1; cancer colon; pancreatic cancer; colon cancer ... See more keywords

Development of an anti‐BAG3 humanized antibody for treatment of pancreatic cancer

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recommendations! Published in 2019 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12492

Abstract: We have previously shown that secreted BAG3 is a potential target for the treatment of pancreatic ductal adenocarcinoma and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti‐BAG3 murine… read more here.

Keywords: anti bag3; treatment; antibody; pancreatic cancer ... See more keywords

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13230

Abstract: Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic cancer. Smoking is a high‐risk factor for pancreatic cancer and cancer resistance to gemcitabine; however, the underlying mechanisms remain unclear. 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)… read more here.

Keywords: cell; pancreatic cancer; 2ar akt; cancer ... See more keywords

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

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recommendations! Published in 2025 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.70099

Abstract: Despite the recent scientific advancements, pancreatic cancer remains the seventh leading cause of cancer‐related mortality. Pancreatic cancer progression is closely associated with inflammation, and we previously showed that short hairpin RNA‐mediated knockdown of sST2 expression,… read more here.

Keywords: cancer; cancer cells; tumor; pancreatic cancer ... See more keywords
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Intrafractional relationship changes between an external breathing signal and fiducial marker positions in pancreatic cancer patients

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recommendations! Published in 2020 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12841

Abstract: Abstract Background and purpose The purpose of this study of pancreatic cancer patients treated with respiratory‐guided stereotactic body radiotherapy (SBRT) on a standard linac was to investigate (a) the intrafractional relationship change (IRC) between a… read more here.

Keywords: treatment delivery; cancer patients; treatment; pancreatic cancer ... See more keywords