Overexpression of TRIM32 promotes pancreatic β‐cell autophagic cell death through Akt/mTOR pathway under high glucose conditions
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11897
Abstract: Type 2 diabetes mellitus (T2DM) is a growing worldwide epidemic and is characterized by progressive pancreatic β‐cell dysfunction and insulin resistance. Tripartite motif protein 32 (TRIM32) belongs to the TRIM family protein and has been… read more here.
Keywords: cell; pancreatic cell; akt mtor; high glucose ... See more keywords
Long non-coding RNA-regulated pathways in pancreatic β cells: Their role in diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.007
Abstract: Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that have not coding potential, but act as gene expression regulators through several molecular mechanisms. Several studies have identified tons of lncRNAs that are… read more here.
Keywords: pancreatic cell; long non; non coding; pancreatic cells ... See more keywords
Carvedilol prevents pancreatic β-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-κB, COX-2, iNOS and oxidative stress.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155394
Abstract: Inflammation is one of the main mechanisms of pancreatic β-cell damage and the development of type 1 diabetes (T1D). Carvedilol, a beta-adrenergic receptor blocker, has been demonstrated to have anti-inflammatory and antioxidant effects. The aim… read more here.
Keywords: damage development; pancreatic cell; carvedilol; cell damage ... See more keywords
Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.007
Abstract: The Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) is an enzyme that has been implicated as an important drug target in various therapeutic areas, including neurological disorders (Down syndrome, Alzheimer's disease), oncology, and diabetes (pancreatic β-cell… read more here.
Keywords: dyrk1a; pancreatic cell; dyrk1a inhibitor; thiadiazine ... See more keywords
Computational modeling of the effect of temperature variations on human pancreatic β-cell activity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thermal biology"
DOI: 10.1016/j.jtherbio.2018.05.006
Abstract: The effect of temperature variations on the pancreatic β-cell activity and the role of different model compartments in temperature sensing have been investigated using a computational modeling approach. The results of our study show that… read more here.
Keywords: pancreatic cell; temperature; effect temperature; temperature variations ... See more keywords
NR3C1/Glucocorticoid receptor activation promotes pancreatic β-cell autophagy overload in response to glucolipotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2200625
Abstract: Diabetes is a complex and heterogeneous disorder characterized by chronic hyperglycemia. Its core cause is progressively impaired insulin secretion by pancreatic β-cell failures, usually upon a background of pre-existing insulin resistance. Recent studies demonstrate that… read more here.
Keywords: cell; glucocorticoid receptor; pancreatic cell; nr3c1 glucocorticoid ... See more keywords
Proteome-Wide Protein Expression Profiling Across Five Pancreatic Cell Lines
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000800
Abstract: Objectives Mass spectrometry–based proteomics enables near-comprehensive protein expression profiling. We aimed to compare quantitatively the relative expression levels of thousands of proteins across 5 pancreatic cell lines. Methods Using tandem mass tags (TMT10-plex), we profiled… read more here.
Keywords: protein expression; cell lines; pancreatic cell; cell ... See more keywords
Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Diabetic Medicine"
DOI: 10.1111/dme.14984
Abstract: Tetraspanin‐7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate β‐cell L‐type Ca2+ channel activity. However, the role of Tspan7 in pancreatic β‐cell function is not yet fully understood. read more here.
Keywords: cell; tetraspanin expression; pancreatic cell; loss tetraspanin ... See more keywords
Promoting pancreatic β cell proliferation: A powerful key for realizing regenerative therapy for diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13967
Abstract: This commentary is on a recent report on the regulation mechanism of beta cell proliferation. read more here.
Keywords: cell; cell proliferation; pancreatic cell; proliferation powerful ... See more keywords
Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/4614379
Abstract: Bisphenol A (BPA) and phthalates are common environmental contaminants that have been proposed to influence incidence and development of types 1 and 2 diabetes. Thus, effects of BPA and three phthalate metabolites (monoisobutyl phthalate (MiBP),… read more here.
Keywords: phthalate metabolites; pancreatic cell; phthalate; bpa ... See more keywords
Nonalcoholic Fatty Liver Hepatocyte-Derived lncRNA MALAT1 Aggravates Pancreatic Cell Inflammation via the Inhibition of Autophagy by Upregulating YAP
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/2930960
Abstract: Background Acute pancreatitis (AP) is one of the most common gastrointestinal disorders, which causes death with a high mortality rate of about 30%. The study aims to identify whether the nonalcoholic fatty liver disease (NAFLD)-derived… read more here.
Keywords: nonalcoholic fatty; nafld derived; cell; fatty liver ... See more keywords