Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.4254
Abstract: Key Points Question Is antibiotic therapy associated with response to chemotherapy in patients with metastatic pancreatic ductal adenocarcinoma (PDAC)? Findings In this cohort study of 3850 older adults with metastatic PDAC, receipt of perichemotherapy antibiotics… read more here.
Keywords: metastatic pancreatic; ductal adenocarcinoma; survival among; pancreatic ductal ... See more keywords
An Emerging Paradigm for Germline Testing in Pancreatic Ductal Adenocarcinoma and Immediate Implications for Clinical Practice: A Review.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.5963
Abstract: Importance Pancreatic ductal adenocarcinoma (PDAC) is a malignant neoplasm with a rising incidence and is a leading public health challenge. Pancreatic ductal adenocarcinoma has been well characterized genomically, with findings of therapeutic actionability that have… read more here.
Keywords: ductal adenocarcinoma; pancreatic ductal; implications clinical; germline ... See more keywords
A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12364
Abstract: Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compounds that effectively… read more here.
Keywords: therapeutic agent; ductal adenocarcinoma; pancreatic ductal; cancer cells ... See more keywords
Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13344
Abstract: The modest clinical benefits of neoadjuvant chemotherapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) are associated with a lack of robust data on treatment‐induced changes in the tumor. To this end, comparative proteomic profiling of tumor… read more here.
Keywords: neoadjuvant chemotherapy; ductal adenocarcinoma; expression; pancreatic ductal ... See more keywords
In Situ Formed ROS-responsive Hydrogel with STING Agonist and Gemcitabine to Intensify immunotherapy Against Pancreatic Ductal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203264
Abstract: Immunotherapy, the most revolutionary anticancer strategy, faces major obstacles in yielding desirable outcomes in pancreatic ductal adenocarcinoma (PDAC) due to the highly immunosuppressive tumor microenvironment (TME). Meanwhile, when used alone, the traditional first-line chemotherapeutic agent… read more here.
Keywords: sting agonist; immunotherapy; hydrogel; ductal adenocarcinoma ... See more keywords
Visual Investigation of Tumor-Promoting Fibronectin Potentiated By Obesity In Pancreatic Ductal Adenocarcinoma Using An Mr/Nirf Dual-Modality Dendrimer Nanoprobe.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300787
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by dense stroma. Obesity is an important metabolic factor that greatly increases PDAC risk and mortality, worsens progression and leads to poor chemotherapeutic outcomes. Withomics analysis,… read more here.
Keywords: dual modality; nirf dual; ductal adenocarcinoma; obesity ... See more keywords
Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201902926
Abstract: Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignant cancer with complex genomic variations, and no targetable genomic lesions have been found yet. Super‐enhancers (SEs) have been found to contribute to the continuous and robust… read more here.
Keywords: pdac; drug; pancreatic ductal; ductal adenocarcinoma ... See more keywords
PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
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DOI: 10.1002/advs.202202448
Abstract: The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the exchange of GDP for GTP on RAS. However, regulation of the GEF activity remains elusive. Here, the authors report that PPDPF functions as an important regulator… read more here.
Keywords: sos1; ductal adenocarcinoma; ppdpf; gef activity ... See more keywords
Relationship between tumour size and outcome in pancreatic ductal adenocarcinoma
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DOI: 10.1002/bjs.10471
Abstract: The size of pancreatic ductal adenocarcinoma (PDAC) at diagnosis is an indicator of outcome. Previous studies have focused mostly on patients with resectable disease. The aim of this study was to investigate the relationship between… read more here.
Keywords: tumour size; relationship tumour; size; pancreatic ductal ... See more keywords
Research progress and design optimization of CAR‐T therapy for pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2430
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer with limited treatment options. Chimeric antigen receptor T cells (CAR‐T) are genetically engineered T cells that can specifically kill tumor cells without major histocompatibility complex restriction.… read more here.
Keywords: car therapy; car; pancreatic ductal; ductal adenocarcinoma ... See more keywords
A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2526
Abstract: To investigate whether the relative computed tomography (CT) value (rCT) of adjacent pancreatic parenchyma can distinguish focal‐type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). read more here.
Keywords: pancreatic ductal; ductal adenocarcinoma; type autoimmune; focal type ... See more keywords