Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4302-7
Abstract: Aims/hypothesisPancreatic beta-like cells generated from human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells (hESCs) offer an appealing donor tissue source. However, differentiation protocols that mainly use growth factors are costly. Therefore, in… read more here.
Keywords: embryonic pancreatic; differentiation; mouse embryonic; endocrine ... See more keywords
Zebrafish model of KRAS-initiated pancreatic endocrine tumor
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DOI: 10.1080/19768354.2019.1610058
Abstract: ABSTRACT Pancreatic cancer constitutes a genetic disease in which somatic mutations in the KRAS proto-oncogene are detected in 95% of cases. Activation of the KRAS proto-oncogene represents an initiating event in pancreatic tumorigenesis. Here, we… read more here.
Keywords: endocrine tumors; zebrafish model; endocrine; pancreatic endocrine ... See more keywords
Association of fatty pancreas with pancreatic endocrine and exocrine function
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DOI: 10.1371/journal.pone.0209448
Abstract: Aim The purpose of this study was to clarify whether fatty pancreas might lead to impaired pancreatic endocrine or exocrine function. Material and methods The study involved 109 participants who had undergone the glucagon stimulation… read more here.
Keywords: fatty pancreas; exocrine; impairment; function ... See more keywords
The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation
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DOI: 10.2337/db20-0883
Abstract: The allocation and specification of pancreatic endocrine lineages are tightly regulated by transcription factors. Disturbances in differentiation of these lineages contribute to the development of various metabolic diseases, including diabetes. The insulinoma-associated protein 1 (Insm1),… read more here.
Keywords: domain insm1; pancreatic endocrine; cell; snag domain ... See more keywords
Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation
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DOI: 10.3390/ijms21165867
Abstract: Diabetes is one of the leading causes of death globally. Currently, the donor pancreas is the only source of human islets, placing extreme constraints on supply. Hence, it is imperative to develop renewable islets for… read more here.
Keywords: pancreatic endocrine; differentiation; pluripotent stem; stem ... See more keywords
Innervation modulates the functional connectivity between pancreatic endocrine cells
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DOI: 10.7554/elife.64526
Abstract: The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this question, we established an in vivo imaging model that also allows chronic and acute neuromodulation with genetic and… read more here.
Keywords: innervation; activity; connectivity pancreatic; delta cells ... See more keywords