Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.10.003
Abstract: An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective macroencapsulation devices for the treatment of type 1 diabetes. We report an… read more here.
Keywords: peptide; type diabetes; pancreatic endoderm; cell ... See more keywords
Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats
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DOI: 10.1177/09636897231167323
Abstract: Subcutaneous implants of device-encapsulated stem cell–derived pancreatic endoderm (PE) can establish a functional beta cell mass (FBM) with metabolic control in immune-compromised mice. In a study with human-induced pluripotent stem cell-PE, this outcome was favored… read more here.
Keywords: cell; beta; derived pancreatic; nude rats ... See more keywords
Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
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DOI: 10.2337/db18-0788
Abstract: The paucity of human donors limits broadened application of β-cell replacement therapy. Insulin-producing cells derived from human embryonic stem cells (hESCs) have recently been investigated clinically as a feasible surrogate to primary tissue. Herein, we… read more here.
Keywords: long term; posttransplant characterization; pancreatic endoderm; hesc derived ... See more keywords
The impact of different implantation sites and sex on the differentiation of human pancreatic endoderm cells into insulin-secreting cells in vivo.
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DOI: 10.2337/db22-0692
Abstract: Few studies have examined the differentiation of human embryonic stem cell (hESC)-derived pancreatic endoderm cells (PECs) in different implantation sites. Here, we investigate the influence of implantation site and recipient sex on the differentiation of… read more here.
Keywords: implantation sites; pancreatic endoderm; hesc derived; differentiation human ... See more keywords