Tissue‐engineering approaches in pancreatic islet transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26821
Abstract: Pancreatic islet transplantation is a promising alternative to whole‐pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing… read more here.
Keywords: pancreatic islet; islet; islet transplantation; transplantation ... See more keywords
Co‐microencapsulation of human umbilical cord‐derived mesenchymal stem and pancreatic islet‐derived insulin producing cells in experimental type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3372
Abstract: Post‐partum umbilical cord Wharton Jelly‐derived adult mesenchymal stem cells (hUCMS) hold anti‐inflammatory and immunosuppressive properties. Human pancreatic islet‐derived progenitor cells (hIDC) may de‐differentiate, and subsequently re‐differentiate into insulin producing cells. The two cell types share… read more here.
Keywords: pancreatic islet; umbilical cord; producing cells; islet derived ... See more keywords
A silk‐based encapsulation platform for pancreatic islet transplantation improves islet function in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.1990
Abstract: The success of pancreatic islet (PI) transplantation is challenged by PI functional damage during the peritransplantation period. A silk‐based encapsulation platform including mesenchymal stromal cells (MSCs) was evaluated for islet cell delivery in vivo. Islet… read more here.
Keywords: pancreatic islet; islet; silk; islet transplantation ... See more keywords
The potential role of multifunctional human amniotic epithelial cells in pancreatic islet transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3214
Abstract: Pancreatic islet cell transplantation has proven efficacy as a treatment for type 1 diabetes mellitus, chiefly in individuals who are refractory to conventional insulin replacement therapy. At present its clinical use is restricted, firstly by… read more here.
Keywords: pancreatic islet; epithelial cells; amniotic epithelial; islet ... See more keywords
Pancreatic Islet Transcriptional Enhancers and Diabetes
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DOI: 10.1007/s11892-019-1230-6
Abstract: Common genetic variants that associate with type 2 diabetes risk are markedly enriched in pancreatic islet transcriptional enhancers. This review discusses current advances in the annotation of islet enhancer variants and their target genes. Recent… read more here.
Keywords: pancreatic islet; enhancers diabetes; transcriptional enhancers; islet ... See more keywords
PET probes for imaging pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-017-0251-x
Abstract: PurposePET can detect very low concentrations of the probes at subpicomolar range in the target tissue with high sensitivity. The development of PET probes for imaging pancreatic islet cells depends on several key elements: the… read more here.
Keywords: imaging pancreatic; pancreatic islet; probes imaging; pet probes ... See more keywords
Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.12.011
Abstract: Bioengineering approaches to regulate stem cell fates aim to recapitulate the in vivo microenvironment. In recent years, manipulating the micro- and nano-scale topography of the stem cell niche has gained considerable interest for the purposes… read more here.
Keywords: pancreatic islet; gradient pattern; islet like; stem ... See more keywords
Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Reports"
DOI: 10.1016/j.celrep.2022.110377
Abstract: Summary The precise developmental dynamics of the pancreatic islet endocrine cell types, and their interrelation, are unknown. Some authors claim the persistence of islet cell differentiation from precursor cells after birth (“neogenesis”). Here, using four… read more here.
Keywords: hormone expressing; islet; expressing cells; cell ... See more keywords
The HETE Is on FFAR1 and Pancreatic Islet Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.01.006
Abstract: It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate… read more here.
Keywords: pancreatic islet; islet cells; ffar1 pancreatic; hete ffar1 ... See more keywords
Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.01.015
Abstract: Every animal species has a signature blood glucose level or glycemic set point. These set points are different, and the normal glycemic levels (normoglycemia) of one species would be life threatening for other species. Mouse… read more here.
Keywords: pancreatic islet; set point; paracrine interactions; glycemic set ... See more keywords
Effects of Y1 receptor agonist on the pancreatic islet of diet-induced obese and diabetic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2020.107669
Abstract: AIMS Agonists of the NPY receptor might be potential in protecting pancreatic islets from injury. We aimed to characterize the role of [Leu31, Pro34]-PYY, an NPYR1 agonist, in pancreatic islets of a diet-induced obesity and… read more here.
Keywords: insulin; pancreatic islet; diet induced; islet ... See more keywords