Pancreatic Islets as a Target of Adipokines.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210044
Abstract: Rising rates of obesity are intricately tied to the type 2 diabetes epidemic. The adipose tissues can play a central role in protection against or triggering metabolic diseases through the secretion of adipokines. Many adipokines… read more here.
Keywords: beta; target adipokines; islets target; physiology ... See more keywords
Comparison of different compressed sensing algorithms for low SNR 19F MRI applications—Imaging of transplanted pancreatic islets and cells labeled with perfluorocarbons
Sign Up to like & getrecommendations! Published in 2017 at "NMR in Biomedicine"
DOI: 10.1002/nbm.3776
Abstract: Transplantation of pancreatic islets is a possible treatment option for patients suffering from Type I diabetes. In vivo imaging of transplanted islets is important for assessment of the transplantation site and islet distribution. Thanks to… read more here.
Keywords: compressed sensing; 19f mri; pancreatic islets; snr ... See more keywords
Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000176
Abstract: Proteasomal spliced peptides (PSPs) have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel neoantigens that can stimulate highly specific T cells. Much debate has… read more here.
Keywords: identification spliced; modified peptides; peptides pancreatic; spliced peptides ... See more keywords
Detection of Glycosaminoglycans in Pancreatic Islets and Lymphoid Tissues.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1398-6_53
Abstract: In this chapter, we describe the detection of the glycosaminoglycans hyaluronan and heparan sulfate in pancreatic islets and lymphoid tissues. The identification of hyaluronan in tissues is achieved by utilizing a highly specific hyaluronan binding… read more here.
Keywords: detection glycosaminoglycans; hyaluronan; heparan sulfate; tissue ... See more keywords
Manipulation and Measurement of AMPK Activity in Pancreatic Islets.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7598-3_26
Abstract: The role of the energy sensor AMPK-activated protein kinase (AMPK) in the insulin-secreting β-cell remains unclear and a subject of intense research. With this chapter, we aim to provide a detailed description of the methods… read more here.
Keywords: manipulation measurement; measurement ampk; ampk activity; pancreatic islets ... See more keywords
Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-022-06658-3
Abstract: Bioengineered pancreatic β-islets have been widely advocated for the research and treatment of diabetes by offering both suitable cell culture models for the study of the pathology and the testing of new drugs and a… read more here.
Keywords: development; vascularized pancreatic; pancreatic islets; cell ... See more keywords
A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.12.003
Abstract: The pancreatic islets of Langerhans regulate glucose homeostasis. The loss of insulin-producing β cells within islets results in diabetes, and islet transplantation from cadaveric donors can cure the disease. In vitro production of whole islets, not… read more here.
Keywords: islet; peninsular structure; morphogenesis; differentiation ... See more keywords
Selective beta-cell toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin on isolated pancreatic islets.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.129103
Abstract: An association between exposure to environmental pollutants and diabetes risk has been repeatedly shown by epidemiological studies. However, the biological basis of this association still need to be clarified. In this research we explored the… read more here.
Keywords: dioxin; exposure; beta; tetrachlorodibenzo dioxin ... See more keywords
Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172518
Abstract: Minocycline functions as a therapeutic drug in different diseases because of its cytoprotective properties. In the present study, we examined the potential of minocycline to decrease the islet loss in pre-transplantation culture stage. Pancreatic islets… read more here.
Keywords: minocycline; apoptosis mediated; death; amelioration apoptosis ... See more keywords
The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.07.005
Abstract: Advanced glycation end-products (AGEs) are produced by non-enzymatic glycation between protein and reducing sugar such as glucose. Although glyceraldehyde-derived AGEs (Glycer-AGEs), one of the AGEs subspecies, have been reported to be involved in the pathogenesis… read more here.
Keywords: products ages; end products; glycation end; pancreatic islets ... See more keywords
Single-cell transcriptomics of East-Asian pancreatic islets cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05266-4
Abstract: Single-cell RNA-seq (scRNA-seq) of pancreatic islets have reported on α- and β-cell gene expression in mice and subjects of predominantly European ancestry. We aimed to assess these findings in East-Asian islet-cells. 448 islet-cells were captured… read more here.
Keywords: single cell; cell; cell transcriptomics; expression ... See more keywords