Evaluation of selected commercial pharmacotherapeutic drugs as potential pancreatic lipase inhibitors and antiproliferative compounds
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DOI: 10.1002/ddr.21499
Abstract: In this study, 15 commercial acidic drugs have been evaluated for pancreatic lipase (PL) inhibitory activity using an in vitro spectrophotometric method. The acidity was the basis of selection, since most PL inhibitors exhibit acidic… read more here.
Keywords: selected commercial; evaluation selected; activity; pancreatic lipase ... See more keywords
In-vitro antiobesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12417
Abstract: BACKGROUND Pancreatic lipase (PL) is a key lipolytic enzyme in humans for the digestion and absorption of dietary fats. Thereby, PL is a well-recognized target in the management of obesity and its inhibition attracts the… read more here.
Keywords: inhibition; activity; pancreatic lipase; method ... See more keywords
High-theabrownins instant dark tea product by Aspergillus niger via submerged fermentation: α-glucosidase and pancreatic lipase inhibition and antioxidant activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8387
Abstract: BACKGROUND Theabrownins (TB) are bioactive components that are usually extracted from Chinese dark tea, in which they are present at low concentrations. The present study aimed to produce an instant dark tea high in theabrownins… read more here.
Keywords: high theabrownins; fermentation; pancreatic lipase; instant dark ... See more keywords
Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship and ultra- high-performance liquid chromatography-tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200541
Abstract: As a traditional Chinese medicine, Schisandra chinensis has potential weight-loss effect by delaying carbohydrate absorption and improving lipid metabolic disorders. However, its active components are still unclear and require in-depth research. In this study, the… read more here.
Keywords: performance liquid; alpha glucosidase; schisandra chinensis; liquid chromatography ... See more keywords
Development and Optimization of a High-Throughput Screening Assay for Rapid Evaluation of Lipstatin Production by Streptomyces Strains
Sign Up to like & getrecommendations! Published in 2017 at "Current Microbiology"
DOI: 10.1007/s00284-017-1420-x
Abstract: Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone… read more here.
Keywords: lipstatin; lipstatin production; pancreatic lipase; lipase ... See more keywords
The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2017.05.010
Abstract: Abstract The molecular interactions between pancreatic lipase (PL) and five triterpenoid saponins compounds, including tea saponin, oleanolic acid, betulin, ginsenoside Ro, and ginsenoside Rd, were investigated in vitro through comprehensive evaluation of PL activity, conformation,… read more here.
Keywords: kinetics thermodynamics; activity conformation; triterpenoid saponins; thermodynamics ... See more keywords
Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.07.011
Abstract: Pancreatic lipase (PL), a key enzyme responsible for the hydrolysis of triacylglycerides in the gastrointestinal tract, has been identified as the therapeutic target for the regulation of lipid absorption. In the present study, six major… read more here.
Keywords: medicine; mori radicis; pancreatic lipase; cortex mori ... See more keywords
Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.012
Abstract: A series of eighteen indole glyoxylamide analogues were synthesized, characterized and evaluated for their pancreatic lipase inhibitory activity. Porcine pancreatic lipase (Type II) was used with 4-nitrophenyl butyrate (as substrate) for the in vitro assay.… read more here.
Keywords: design synthesis; biological evaluation; pancreatic lipase; lipase ... See more keywords
Gallotannins are uncompetitive inhibitors of pancreatic lipase activity.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106409
Abstract: Inhibition of pancreatic lipase (PL) is used to treat dyslipidemias and obesity. Phenolic compounds are highly bioactive molecules that can inhibit various enzymes. Our aim was to evaluate the inhibitory activity of selected phenolic compounds… read more here.
Keywords: gallotannins uncompetitive; pancreatic lipase; activity; inhibitors pancreatic ... See more keywords
The inhibitory effects of an eight-herb formula (RCM-107) on pancreatic lipase: enzymatic, HPTLC profiling and in silico approaches
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e02453
Abstract: Aims Obesity is a global, public health issue that causes or exacerbates serious medical disorders. Chinese herbal therapies have become one of the most popular alternatives due to intolerances of current anti-obesity treatments. The RCM-107… read more here.
Keywords: formula; hptlc profiling; pancreatic lipase; profiling silico ... See more keywords
Molecular recognition between pancreatic lipase and natural and synthetic inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.01.150
Abstract: Pancreatic lipase (PL) is a primary lipase critical for triacylglyceride digestion in humans and is considered as a promising target for the treatment of obesity. Although the current synthetic drugs available for treating obesity have… read more here.
Keywords: molecular recognition; lipase; pancreatic lipase; heterodimer complex ... See more keywords