Abstract C56: Bmi1 is widely expressed in acini and regulates Kras-driven transcription factor networks in early pancreatic neoplasia
Sign Up to like & getrecommendations! Published in 2019 at "Robotics and Autonomous Systems"
DOI: 10.1158/1538-7445.panca19-c56
Abstract: Rare acinar cells expressing Bmi1, a component of the Polycomb Repressor Complex 1 (PRC1), represent a reservoir of cells contributing to pancreatic repair during injury and stress. This is marked by acinar-ductal metaplasia (ADM), a… read more here.
Keywords: creer; pancreatic neoplasia; acinar cells; kras driven ... See more keywords
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer
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DOI: 10.18632/oncotarget.21539
Abstract: Peroxiredoxin-1 (Prdx1), a member of the thioredoxin (Txn) system, is overexpressed and correlates with poor prognosis in pancreatic cancer patients and can suppress Kras signaling through redox-mediated inhibition of ERK and AKT in lung and… read more here.
Keywords: system; txn; expression; pancreatic neoplasia ... See more keywords