Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.018
Abstract: The proliferation of human pancreatic progenitor cells (PPCs) is critical for developing cell therapies for diabetes. Here, using transcriptome analysis combined with small interfering RNA (siRNA) screening, we revealed that WNT7B is a downstream growth… read more here.
Keywords: wnt7b; proliferation; human pancreatic; non canonical ... See more keywords
Human expandable pancreatic progenitor–derived β cells ameliorate diabetes
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DOI: 10.1126/sciadv.abk1826
Abstract: An unlimited source of human pancreatic β cells is in high demand. Even with recent advances in pancreatic differentiation from human pluripotent stem cells, major hurdles remain in large-scale and cost-effective production of functional β… read more here.
Keywords: progenitor derived; pancreatic progenitor; expandable pancreatic; progenitor ... See more keywords
Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters
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DOI: 10.3390/ijms20174083
Abstract: Pancreatic progenitor cells (PPCs) are the primary source for all pancreatic cells, including beta-cells, and thus the proliferation and differentiation of PPCs into islet-like cell clusters (ICCs) opens an avenue to providing transplantable islets for… read more here.
Keywords: proliferation; differentiation; pancreatic progenitor; function ... See more keywords