Cytokine Profiling and Orthotopic Xenografing of Pancreatic Stellate Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8879-2_14
Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most lethal human malignancies with a poor prognosis due to systemic metastasis and a high recurrence rate. Interactions between tumor and stromal cells play a… read more here.
Keywords: pancreatic stellate; profiling orthotopic; cytokine profiling; xenografing pancreatic ... See more keywords
Enzyme-mediated stiffening hydrogels for probing activation of pancreatic stellate cells.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2016.10.027
Abstract: The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor progression, but also hinders the development of therapeutic strategies against pancreatic cancer. Residing… read more here.
Keywords: hydrogel; pancreatic stellate; matrix; tyrosinase ... See more keywords
Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.05.001
Abstract: Pancreatic cancer is refractory and is characterized by extensively surrounding and intratumor fibrotic reactions that are contributed by activated pancreatic stellate cells (PSCs). Herein, we show that CCAAT/enhancer-binding protein δ (CEBPD) responds to transforming growth… read more here.
Keywords: hepatoma derived; pancreatic stellate; growth factor; factor ... See more keywords
YAP1-mediated pancreatic stellate cell activation inhibits pancreatic cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.07.015
Abstract: Pancreatic stellate cells (PSCs) are activated in pancreatic ductal adenocarcinoma (PDAC) and are responsible for dense desmoplastic stroma. Yes-associated protein 1 (YAP1) can induce cancer-associated fibroblast activation in liver and breast tumors, but its effect… read more here.
Keywords: pancreatic stellate; pancreatic cancer; activation; cancer cell ... See more keywords
Nicotine promotes activation of human pancreatic stellate cells through inducing autophagy via α7nAChR-mediated JAK2/STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117301
Abstract: AIM Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was… read more here.
Keywords: jak2 stat3; pancreatic stellate; 7nachr mediated; mediated jak2 ... See more keywords
ASIC1a involves acidic microenvironment-induced activation and autophagy of pancreatic stellate cells
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra03679a
Abstract: Acid-sensing ion channel 1a (ASIC1a), as a member of the proton-gated cation channel family, can be activated by low extracellular pH, and takes part in many acidity-associated physiopathological processes. However, whether ASIC1a is expressed in… read more here.
Keywords: activation autophagy; pscs; asic1a; pancreatic stellate ... See more keywords
Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer via the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01039a
Abstract: Pancreatic stellate cells (PSCs) constitute the fibrotic tumor microenvironment composed of the stroma matrix, which blocks the penetration of gemcitabine (GEM) in pancreatic adenocarcinoma (PDAC) and results in chemoresistance. We analyzed the expression of α-SMA,… read more here.
Keywords: gem; pancreatic stellate; pancreatic cancer; ato ... See more keywords
CXCL12 secreted by pancreatic stellate cells accelerates gemcitabine resistance of pancreatic cancer by enhancing glycolytic reprogramming
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2091019
Abstract: ABSTRACT Pancreatic stellate cells (PSCs) are the primary cell components of pancreatic cancer (PC) and are involved in tumor growth, metastasis and resistance. However, the role and the mechanism of PSCs in gemcitabine (GEM) resistance… read more here.
Keywords: stellate cells; gem; pancreatic stellate; pancreatic cancer ... See more keywords
Fatty Acid–Mediated Stromal Reprogramming of Pancreatic Stellate Cells Induces Inflammation and Fibrosis That Fuels Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000943
Abstract: Objectives Pancreatic ductal adenocarcinoma is one of the deadliest diseases worldwide. Fatty acids (FAs) have properties that affect both cancer cells and tumor environment. We assessed the effects of FAs on malignant characteristics in a… read more here.
Keywords: cancer; inflammation fibrosis; pancreatic cancer; pancreatic stellate ... See more keywords
Targeting of Smad7 in Mesenchymal Cells Does Not Exacerbate Fibrosis During Experimental Chronic Pancreatitis
Sign Up to like & getrecommendations! Published in 2021 at "Pancreas"
DOI: 10.1097/mpa.0000000000001951
Abstract: Objectives Transforming growth factor-β (TGF-β)–mediated accumulation of extracellular matrix proteins such as collagen I is a common feature of fibrosis. Pancreatic stellate cells play an integral role in the pathogenesis of pancreatitis, and their profibrotic… read more here.
Keywords: pancreatitis; targeting smad7; chronic pancreatitis; fibrosis ... See more keywords
A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Research"
DOI: 10.1155/2018/7361684
Abstract: Background Our previous studies have shown that islet stellate cell (ISC), similar to pancreatic stellate cell (PSC) in phenotype and biological characters, may be responsible for the islet fibrosis in type 2 diabetes. To further… read more here.
Keywords: stellate cell; pancreatic stellate; islet stellate; analysis ... See more keywords