Bioimprint Mediated Label‐Free Isolation of Pancreatic Tumor Cells from a Healthy Peripheral Blood Cell Population
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000054
Abstract: New techniques are required for earlier diagnosis and response to treatment of pancreatic cancer. Here, a label‐free approach is reported in which circulating pancreatic tumor cells are isolated from healthy peripheral blood cells via cell… read more here.
Keywords: pancreatic tumor; tumor cells; peripheral blood; cell ... See more keywords
Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced functional materials"
DOI: 10.1002/adfm.202000545
Abstract: Tumor progression relies heavily on the interaction between the neoplastic epithelial cells and their surrounding stromal partners. This cell cross-talk affects stromal development, and ultimately the heterogeneity impacts drug efflux and efficacy. To mimic this… read more here.
Keywords: pancreatic tumor; tumor microenvironment; organ chip; tumor ... See more keywords
Pancreatic Tumor-targeting Stemsome Therapeutics.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202300934
Abstract: Owing to the intrinsic ability of stem cells to target the tumor environment, stem cell membrane-functionalized nanocarriers can target and load active anticancer drugs. In this study, a strategy that focuses on stem cells that… read more here.
Keywords: tumor targeting; targeting stemsome; pancreatic tumor; tumor ... See more keywords
Orthotopic Pancreatic Tumor Mouse Models of Liver Metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8879-2_27
Abstract: The survival from pancreatic cancer is poor because most patients are diagnosed after the cancer has metastasized. Liver is the most common site of pancreatic cancer metastasis. Orthotopic mouse models of liver metastasis by intrasplenically… read more here.
Keywords: pancreatic tumor; mouse models; models liver; metastasis ... See more keywords
Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate].
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109525
Abstract: The ERBB1/2/4 inhibitor neratinib causes plasma membrane-associated K-RAS to mislocalize into intracellular vesicles; this effect is enhanced by HDAC inhibitors and the combination of [neratinib + sodium valproate] is now a phase I trial (NCT03919292).… read more here.
Keywords: neratinib valproate; pancreatic tumor; pi3k; valproate ... See more keywords
A rare pancreatic tumor mimicking chronic calcified pancreatitis
Sign Up to like & getrecommendations! Published in 2023 at "Endoscopy"
DOI: 10.1055/a-2051-8053
Abstract: A 48-year-old woman was admitted for severe upper abdominal pain, with impressive dilation and multiple high-density stones in the main pancreatic duct (PD). The patient was diagnosed with “chronic pancreatitis” and a therapeutic endoscopic retrograde… read more here.
Keywords: tumor mimicking; patient; rare pancreatic; pancreatitis ... See more keywords
Modeling of magnetoliposome uptake in human pancreatic tumor cells in vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Nanotechnology"
DOI: 10.1088/1361-6528/ab033e
Abstract: The internalization kinetics resulting from magnetic nanoparticle interactions with tumor cells play an important role in nanoparticle-based cancer treatment efficiency. Here, the uptake kinetics of magnetoliposomes (ML) into human pancreatic tumor cells (MiaPaCa-2 and BxPC-3)… read more here.
Keywords: uptake kinetics; pancreatic tumor; internalization; tumor cells ... See more keywords
Endoscopic pancreatic duct stenting combined with 3D laparoscopic pancreatic tumor resection: Three case reports
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DOI: 10.1097/md.0000000000033733
Abstract: Rationale: This study explored the safety and feasibility of 3D laparoscopy and intraoperative ultrasound techniques, which made minimally invasive pancreatic surgery more precise and detailed. Patient concern: Case 1 was a 51-year-old man with a… read more here.
Keywords: laparoscopic pancreatic; case; pancreatic duct; pancreatic tumor ... See more keywords
GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0778
Abstract: Glypican-1 (GPC1) is a cell surface proteoglycan that is upregulated in multiple types of human cancers including pancreatic cancer. Here, we investigated whether GPC1 could be a target of antibody-toxin fusion proteins (i.e. immunotoxins) for… read more here.
Keywords: tumor growth; gpc1 targeted; immunotoxin; gpc1 ... See more keywords
Abstract 2674: Synergistic combinations of lurbinectedin with irinotecan and ONC212 in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2674
Abstract: Pancreatic cancer is a devastating disease with a five-year survival rate below 10% according to the American Cancer Society. Novel chemotherapeutics and targeted therapies in pancreatic cancer have shown limited success, illustrating the urgent need… read more here.
Keywords: pancreatic cancer; irinotecan onc212; pancreatic tumor; lurbinectedin irinotecan ... See more keywords
Abstract IA-15: Metabolic networks in the pancreatic tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.panca20-ia-15
Abstract: Pancreatic tumors are dynamic pseudo-organs that contain numerous cell types interacting to create unique physiology. A typical pancreatic tumor is made up largely of stromal fibroblasts and immune cell populations, rather than cancer cells. These… read more here.
Keywords: pancreatic tumor; pancreatic cancer; cancer cells; cancer ... See more keywords