Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202937
Abstract: Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigenesis. However, little is known about its… read more here.
Keywords: setd2 deficiency; immune escape; escape pancreatic; pancreatic tumorigenesis ... See more keywords
IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-15-1684
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here, we show that the noncanonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation. Loss of IKBKE… read more here.
Keywords: kras induced; ikbke required; pancreatic tumorigenesis; induced pancreatic ... See more keywords
Enteroendocrine Cell Formation Is an Early Event in Pancreatic Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.865452
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of only 11%, due, in part, to late diagnosis, making the need to understand early events in tumorigenesis critical. Acinar-to-ductal metaplasia (ADM),… read more here.
Keywords: cell formation; pancreatic tumorigenesis; enteroendocrine cell; tumorigenesis ... See more keywords
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice
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DOI: 10.3390/cancers14030796
Abstract: Simple Summary Pancreatic cancer is a highly fatal disease that does not respond well to current cancer therapies. We previously showed that protein kinase C iota (PKCι) is highly expressed in pancreatic cancer, and inhibition… read more here.
Keywords: cell; pancreatic cancer; pancreatic tumorigenesis; cancer ... See more keywords
PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism
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DOI: 10.7150/ijbs.77150
Abstract: MLL-AFF4 fusion gene has been discovered in acute leukemia, whether AFF4 alone plays a role in tumor, especially pancreatic tumorigenesis, is still elusive. Increasing evidence suggests that cancer cells altered nucleotide metabolism during tumorigenesis. In… read more here.
Keywords: nucleotide metabolism; pancreatic tumorigenesis; hprt1 impdh2; aff4 ... See more keywords
Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer"
DOI: 10.7150/jca.79905
Abstract: Eyes absent homologue 4 (EYA4) is silenced in pancreatic ductal adenocarcinoma (PDAC) and functions as a tumor suppressor to restrain PDAC development, albeit the molecular mechanism underlying its downregulation remains enigmatic. Methods: Functional studies were… read more here.
Keywords: motif containing; tripartite motif; eya4; pancreatic tumorigenesis ... See more keywords