Investing in antibiotics to alleviate future catastrophic outcomes: What is the value of having an effective antibiotic to mitigate pandemic influenza?
Sign Up to like & getrecommendations! Published in 2019 at "Health Economics"
DOI: 10.1002/hec.3867
Abstract: Over 95% of post-mortem samples from the 1918 pandemic, which caused 50 to 100 million deaths, showed bacterial infection complications. The introduction of antibiotics in the 1940s has since reduced the risk of bacterial infections,… read more here.
Keywords: antibiotics alleviate; investing antibiotics; value; pandemic influenza ... See more keywords
Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3681-x
Abstract: An F35L mutation in the N-terminal domain of the polymerase acidic protein (PA-Nter), which contains the active site of the endonuclease, has been reported to result in higher polymerase activity in mouse-adapted strains of the… read more here.
Keywords: polymerase acidic; influenza h1n1; pandemic influenza; polymerase ... See more keywords
Dynamic changes of lymphocyte counts in adult patients with severe pandemic H1N1 influenza A
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Infection and Public Health"
DOI: 10.1016/j.jiph.2019.05.017
Abstract: Abstract Background Lymphopenia has been observed in severe pandemic influenza A/H1N1 in developed countries. However, data from developing countries are rare and dynamic change of lymphocyte counts in severe pandemic influenza A/H1N1 is scarcely reported.… read more here.
Keywords: h1n1; lymphocyte counts; influenza h1n1; pandemic influenza ... See more keywords
An indirect comparison meta-analysis of AS03 and MF59 adjuvants in pandemic influenza A(H1N1)pdm09 vaccines.
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DOI: 10.1016/j.vaccine.2019.06.039
Abstract: BACKGROUND Although oil-in-water adjuvants improve pandemic influenza vaccine efficacy, AS03 versus MF59 adjuvant comparisons in A(H1N1)pdm09 pandemic vaccines are lacking. METHODS We conducted an indirect-comparison meta-analysis extracting published data from randomised controlled trials in literature… read more here.
Keywords: h1n1 pdm09; mf59; pandemic influenza; as03 mf59 ... See more keywords
Shaping meeting to explore the value of a coordinated work plan for epidemic and pandemic influenza vaccine preparedness.
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DOI: 10.1016/j.vaccine.2020.02.038
Abstract: In March 2019, a group of global health leaders with expertise in influenza, vaccinology and pandemic preparedness was convened for a meeting titled "Shaping Meeting to explore the value of a coordinated work plan for… read more here.
Keywords: meeting; coordinated work; work plan; influenza ... See more keywords
Seasonal and pandemic influenza: 100 years of progress, still much to learn
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DOI: 10.1038/s41385-020-0287-5
Abstract: Influenza viruses are highly transmissible, both within and between host species. The severity of the disease they cause is highly variable, from the mild and inapparent through to the devastating and fatal. The unpredictability of… read more here.
Keywords: influenza; disease; pandemic influenza; influenza 100 ... See more keywords
Aluminum salts as an adjuvant for pre-pandemic influenza vaccines: a meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29858-w
Abstract: Avian-origin H5/H7 influenza has the potential to cause the next influenza pandemic. Availability of effective vaccines is an essential part of pre-pandemic preparedness. However, avian influenza surface antigens are poorly immunogenic to humans, which necessitates… read more here.
Keywords: pre pandemic; aluminum salts; influenza vaccines; pandemic influenza ... See more keywords
Improving pandemic preparedness through better, faster influenza vaccines
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2021.1886931
Abstract: ABSTRACT Introduction. Timely availability of effective influenza vaccine will be critical to mitigate the next influenza pandemic. The mission of Biomedical Advanced Research and Development Authority (BARDA) is to develop medical countermeasures against pandemics, including… read more here.
Keywords: influenza vaccine; improving pandemic; vaccines improving; pandemic influenza ... See more keywords
Physician's knowledge, attitudes, and practices regarding seasonal influenza, pandemic influenza, and highly pathogenic avian influenza A (H5N1) virus infections of humans in Indonesia
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DOI: 10.1111/irv.12428
Abstract: Indonesia has reported highest number of fatal human cases of highly pathogenic avian influenza (HPAI) A (H5N1) virus infection worldwide since 2005. There are limited data available on seasonal and pandemic influenza in Indonesia. During… read more here.
Keywords: h5n1 virus; highly pathogenic; influenza; h5n1 ... See more keywords
Policy perspectives on post pandemic influenza vaccination in Ghana and Malawi
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DOI: 10.1186/s12889-017-4058-5
Abstract: BackgroundIn the late 1990s, in the context of renewed concerns of an influenza pandemic, countries such as Ghana and Malawi established plans for the deployment of vaccines and vaccination strategies. A new pandemic was declared… read more here.
Keywords: ghana malawi; policy; pandemic influenza; coverage ... See more keywords
Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy
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DOI: 10.1371/journal.pone.0188055
Abstract: Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not well understood. We have analyzed memory… read more here.
Keywords: pregnancy; infection; influenza; pandemic influenza ... See more keywords