Reasons for Discontinuation of Insulin Therapy—Results from the International Diabetes Management Practices Study (IDMPS)
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DOI: 10.2337/db18-1026-p
Abstract: Adherence to insulin therapy is often suboptimal. Understanding patients’ perspectives on drug adherence is essential for identification of barriers to therapy. The IDMPS is a global observational survey on the management of people with type… read more here.
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Initiating Basal Insulin Supported Oral Therapy (BOT) with Insulin Glargine 300 U/mL (Gla-300) Improves Glycemic Control in Patients (Pts) with Type 2 Diabetes (T2DM) without Increasing Hypoglycemia Risk
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DOI: 10.2337/db18-1027-p
Abstract: Toujeo-1, a prospective observational study, investigates the effects of initiating BOT with Gla-300 in insulin-naive pts with T2DM in Germany (n=1,680) and Switzerland, insufficiently controlled (A1c 7.5-10%) on oral antidiabetic drugs (OADs) in daily clinical… read more here.
Keywords: insulin; advisory panel; gmbh; self ... See more keywords
Impact of Background Antihyperglycemic Therapy on Insulin Glargine 300 U/mL (Gla-300) vs. Insulin Degludec 100 U/mL (IDeg-100) in Insulin-Naïve People with T2DM from the BRIGHT Randomized Study
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DOI: 10.2337/db18-1029-p
Abstract: BRIGHT (NCT02738151), the first head-to-head trial of Gla-300 and IDeg-100 in T2DM, is a multicenter, open-label, randomized, parallel-group, 24-week actively controlled study, conducted in insulin-naive participants uncontrolled on current antihyperglycemic drugs. Participants (mean baseline HbA… read more here.
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Triple vs. Dual Therapy with Low-Dose Dapagliflozin plus Saxagliptin vs. Each Monocomponent Added to Metformin in Uncontrolled Type 2 Diabetes
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DOI: 10.2337/db18-1149-p
Abstract: Triple therapy with dapagliflozin (DAPA) 10 mg/d + saxagliptin (SAXA) 5 mg/d added to metformin (MET) has greater efficacy than dual therapy in type 2 diabetes (T2D) inadequately controlled by MET alone. We tested triple… read more here.
Keywords: advisory panel; self; therapy; panel self ... See more keywords
More Subjects Achieved Composite Reductions of =1% HbA1c, =5% Body Weight, and =5 mmHg SBP with Semaglutide vs. Comparators (SUSTAIN 1-5, 7)
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DOI: 10.2337/db18-129-or
Abstract: Semaglutide is a new GLP-1 analog for the once-weekly treatment of type 2 diabetes (T2D). Across the SUSTAIN clinical trial program, subjects with T2D achieved significantly greater reductions in three cardiovascular (CV) risk factors with… read more here.
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Potential Autocrine Effects of Type 2 Diabetes–Related Myokines on Human Skeletal Muscle
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DOI: 10.2337/db18-1902-p
Abstract: Myokines are factors secreted by muscle cells that have been suggested to exert an array of autocrine, paracrine and/or endocrine actions. Secretion of a number of these myokines has been reported to be altered in… read more here.
Keywords: advisory panel; pharmaceuticals inc; self; panel self ... See more keywords
Individual and Combined Glucose-Lowering Effects of Glucagon Receptor Antagonism and Sodium-Glucose Cotransporter 2 Inhibition
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DOI: 10.2337/db18-1942-p
Abstract: Studies suggest that sodium-glucose cotransporter 2 inhibitors (SGLT2i) induce hyperglucagonemia, which might counteract its glucose-lowering ability in type 2 diabetes. In a randomized, placebo-controlled, double-dummy, double-blinded, cross-over study, 12 middle-aged patients with type 2 diabetes… read more here.
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Pathophysiology of Remission in Type 2 Diabetes—The Diabetes Remission Clinical Trial (DiRECT)
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DOI: 10.2337/db18-40-or
Abstract: DiRECT is a prospective, randomised study of type 2 diabetes of 48mmol/mol (n=16; non-responders). At baseline, the two groups were similar (age 53.3±1.2 vs. 53.6±2.2 years, weight 100.3±2.8 vs. 98.2 ±3.9kg, BMI 34.9±0.7 vs. 34.9±1.2kg/m2)… read more here.
Keywords: advisory panel; remission; type diabetes; none ... See more keywords
The Relationships between Retinopathy and Other Vascular Complications in Adults with Long-Standing Diabetes—Results from the Canadian Study of Longevity in Type 1 Diabetes (T1D)
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DOI: 10.2337/db18-600-p
Abstract: We aimed to measure the prevalence of retinopathy in a T1D cohort of 75 adults with T1D duration of ≥50 years, and to determine association with other vascular complications. Participants underwent ultra-widefield retinal imaging and… read more here.
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Frequency of High Blood Pressure and Dyslipidemia in T1D and T2D—Results from the International Diabetes Management Practices Study (IDMPS)
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DOI: 10.2337/db18-621-p
Abstract: Appropriate disease management for people with diabetes requires control of not only blood glucose levels but also blood pressure and serum lipid profiles. The International Diabetes Management Practices Study (IDMPS) is a global observational survey… read more here.
Keywords: advisory panel; speaker9s bureau; self; panel self ... See more keywords
Intervention of the Flash Glucose Sensing Technology on Glycemic Control and Treatment Satisfaction in Patients with Type 2 Diabetes Treated Intensively by Insulin—A Randomized Controlled Trial
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DOI: 10.2337/db18-908-p
Abstract: Objective: To determine the satisfaction from treatment and effectiveness of flash glucose monitoring system (FGM) in patients with type 2 diabetes. Design and Methods: 101 individuals with type 2 diabetes on multiple daily insulin injection… read more here.
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