Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell-derived Wnt3.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220392
Abstract: Menopausal women often face long-term estrogen treatment. G protein-coupled estrogen receptor (GPER) expressed in intestinal crypt was activated by estrogen therapy, but it was unclear whether chronic GPER activation during menopause had an effect on… read more here.
Keywords: paneth; proliferation; chronic gper; gper activation ... See more keywords
P071 Crohn’s Disease is associated with elevated levels of the pro-inflammatory CXCR3 ligands (CXCL9, 10 and 11) with an associated reduction in Paneth cell derived antimicrobial peptides in ex-vivo ileal biopsies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.200
Abstract: Despite an expanding array of treatment options, a significant proportion of patients with Crohn’s Disease (CD) fail to respond to currently available therapies, underpinning the importance of biological insights into disease pathogenesis. The pro-inflammatory chemokines… read more here.
Keywords: pro inflammatory; paneth; ileal biopsies; paneth cell ... See more keywords
DEVELOPMENT OF A PERSONALIZED HUMAN PANETH CELL MODEL USING INTESTINAL ORGANOIDS
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DOI: 10.1093/ibd/izae020.186
Abstract: Paneth cells are a specialized intestinal epithelial cell subtype whose major function is to produce antimicrobial peptides (AMPs). Alterations in Paneth cell function are associated with Crohn’s disease (CD) but the confounding influences of environmental… read more here.
Keywords: paneth cells; significantly increased; paneth; cell ... See more keywords
Intestinal crypts remodel in response to deletion of Notch pathway ligands from Paneth cells
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DOI: 10.1152/physiol.2025.40.s1.1026
Abstract: INTRODUCTION: Notch signaling is a principal niche pathway crucial for intestinal stem cells (ISCs), directing ISC self-renewal and lineage commitment to absorptive enterocytes. Because Notch signaling requires cell-cell contact, Paneth cells are considered to be… read more here.
Keywords: paneth cells; notch; paneth; dll1 dll4 ... See more keywords
A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells
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DOI: 10.1371/journal.pone.0266066
Abstract: HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but… read more here.
Keywords: paneth; high fat; paneth cells; potent hnf4 ... See more keywords
Paneth cells as the cornerstones of intestinal and organismal health: a primer
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216427
Abstract: Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by… read more here.
Keywords: health; paneth; intestinal organismal; cells cornerstones ... See more keywords
Paneth cells inhibit intestinal stem cell proliferation through the bone morphogenic protein 7 pathway under rotavirus-mediated intestinal injury
Sign Up to like & getrecommendations! Published in 2025 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v31.i26.107044
Abstract: BACKGROUND Rotavirus (RV), a primary cause of diarrhea-related mortality in 2021, has been shown to damage intestinal epithelial cells while upregulating intestinal stem cells (ISCs) activities. ISCs within the crypt niche drive the continuous self-renewal… read more here.
Keywords: paneth cells; stem; paneth; protein ... See more keywords