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Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220392
Abstract: Menopausal women often face long-term estrogen treatment. G protein-coupled estrogen receptor (GPER) expressed in intestinal crypt was activated by estrogen therapy, but it was unclear whether chronic GPER activation during menopause had an effect on…
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Keywords:
paneth;
proliferation;
chronic gper;
gper activation ... See more keywords
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Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.200
Abstract: Despite an expanding array of treatment options, a significant proportion of patients with Crohn’s Disease (CD) fail to respond to currently available therapies, underpinning the importance of biological insights into disease pathogenesis. The pro-inflammatory chemokines…
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Keywords:
pro inflammatory;
paneth;
ileal biopsies;
paneth cell ... See more keywords
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3
Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266066
Abstract: HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but…
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Keywords:
paneth;
high fat;
paneth cells;
potent hnf4 ... See more keywords
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2
Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216427
Abstract: Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by…
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Keywords:
health;
paneth;
intestinal organismal;
cells cornerstones ... See more keywords