Paneth Cell Dysfunction Mediates Alcohol‐related Steatohepatitis Through Promoting Bacterial Translocation in Mice: Role of Zinc Deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30945
Abstract: Microbial dysbiosis is associated with alcohol‐related hepatitis (AH), with the mechanisms yet to be elucidated. The present study aimed to determine the effects of alcohol and zinc deficiency on Paneth cell (PC) antimicrobial peptides, α‐defensins,… read more here.
Keywords: zinc deficiency; alcohol related; paneth cell;
Notch inhibition counteracts Paneth cell death in absence of caspase-8
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2368-3
Abstract: Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly… read more here.
Keywords: paneth cell; inhibition; notch; casp8 int ... See more keywords
N-3 polyunsaturated fatty acid-enriched lipid emulsion improves Paneth cell function via the IL-22/Stat3 pathway in a mouse model of total parenteral nutrition.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.032
Abstract: Total parenteral nutrition (TPN) is a life-saving therapy for patients with gastrointestinal dysfunction or failure. Long-term TPN impairs gut barrier function and contributes to infections and poor clinical outcomes. However, the underlying mechanisms of TPN-related… read more here.
Keywords: parenteral nutrition; stat3 pathway; paneth cell; total parenteral ... See more keywords
Mist1 Expression Is Required for Paneth Cell Maturation
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.07.003
Abstract: Background Paneth cells are professional secretory cells found within the small intestinal crypt epithelium. Although their role as part of the innate immune complex providing antimicrobial secretory products is well-known, the mechanisms that control secretory… read more here.
Keywords: secretory; paneth cell; expression; mist1 expression ... See more keywords
Mouse Paneth Cell-Enriched Proteome Enabled by Laser Capture Microdissection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00311
Abstract: Paneth cells are antimicrobial peptide-secreting cells located at the base of the crypts of the small intestine. The proteome of Paneth cells is not well defined because of their coexistence with stem cells, making it… read more here.
Keywords: capture microdissection; cell; laser capture; paneth cells ... See more keywords
miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23298-3
Abstract: The intestinal epithelium is a complex structure that integrates digestive, immunological, neuroendocrine, and regenerative functions. Epithelial homeostasis is maintained by a coordinated cross-talk of different epithelial cell types. Loss of integrity of the intestinal epithelium… read more here.
Keywords: paneth cell; mir 802; cell function; enterocyte differentiation ... See more keywords
Paneth cell alertness to pathogens maintained by vitamin D receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.11.015
Abstract: BACKGROUND Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR). While Paneth cells and their products are known to regulate the commensal and pathogenic microbiota, the role that VDRs… read more here.
Keywords: vdr mice; cell alertness; vdr; paneth cell ... See more keywords
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817376116
Abstract: Significance Paneth cells provide intestinal host defense against pathogens and control the healthy microbiota by secreting antimicrobial peptides. We show that the most abundant secreted Paneth cell products, human defensin HD-5 and HD-6, show a… read more here.
Keywords: degradation; paneth cell; host; antimicrobial peptides ... See more keywords
P071 Crohn’s Disease is associated with elevated levels of the pro-inflammatory CXCR3 ligands (CXCL9, 10 and 11) with an associated reduction in Paneth cell derived antimicrobial peptides in ex-vivo ileal biopsies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.200
Abstract: Despite an expanding array of treatment options, a significant proportion of patients with Crohn’s Disease (CD) fail to respond to currently available therapies, underpinning the importance of biological insights into disease pathogenesis. The pro-inflammatory chemokines… read more here.
Keywords: pro inflammatory; paneth; ileal biopsies; paneth cell ... See more keywords
Implications of Paneth cell dysfunction on gastrointestinal health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000887
Abstract: Purpose of review Paneth cells are specialized, secretory epithelial cells located in the small intestine. Although their existence was first described in 1872, their precise role in the gut remained unclear for over a century.… read more here.
Keywords: cell; disease; paneth cells; dysfunction ... See more keywords
Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1184159
Abstract: Paneth cells (PCs) are intestinal epithelial cells (IECs) that contain eosinophilic granules, which are located in Lieberkühn crypts. An increasing number of animal and human experiments have indicated that PCs are involved in the progression… read more here.
Keywords: gut; development; paneth cell; cell development ... See more keywords