Paneth cells and their multiple functions.
Sign Up to like & getrecommendations! Published in 2022 at "Cell biology international"
DOI: 10.1002/cbin.11764
Abstract: The small intestine mucosa is lined by specialized cells that form the crypt-villus axis, which expands its surface. Among the six intestinal epithelial cell types, the Paneth cell is located at the base of the… read more here.
Keywords: multiple functions; cell; cells multiple; paneth cells ... See more keywords
Synergistic effect of aluminum and ionizing radiation upon ultrastructure, oxidative stress and apoptotic alterations in Paneth cells of rat intestine
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-8392-z
Abstract: Environmental and occupational exposure to aluminum along with ionizing radiation results in serious health problems. This study was planned to investigate the impact of oxidative stress provoked by exposure to ionizing radiation with aluminum administration… read more here.
Keywords: aluminum; ionizing radiation; paneth cells; oxidative stress ... See more keywords
Erratum to: Synergistic effect of aluminum and ionizing radiation upon ultrastructure, oxidative stress and apoptotic alterations in Paneth cells of rat intestine
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9286-9
Abstract: Environmental and occupational exposure to aluminum along with ionizing radiation results in serious health problems. This study was planned to investigate the impact of oxidative stress provoked by exposure to ionizing radiation with aluminum administration… read more here.
Keywords: aluminum; ionizing radiation; paneth cells; oxidative stress ... See more keywords
Glycoproteomic analysis identifies cryptdin-related sequence 1 as O-glycosylated protein modified with α1,2-fucose in the small intestine.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108653
Abstract: The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against… read more here.
Keywords: related sequence; paneth cells; glycoproteomic analysis; small intestine ... See more keywords
Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.085
Abstract: IBD syndromes such as Crohn's disease and ulcerative colitis result from the inflammation of specific intestinal segments. Although many studies have reported on the regenerative response of intestinal progenitor and stem cells to tissue injury,… read more here.
Keywords: response; paneth cells; inflammation; tissue ... See more keywords
Paneth cells mediated the response of intestinal stem cells at the early stage of intestinal inflammation in the chicken.
Sign Up to like & getrecommendations! Published in 2021 at "Poultry science"
DOI: 10.1016/j.psj.2020.11.055
Abstract: The rapid renewal and repair of the intestinal mucosa are based on intestinal stem cells (ISC), which are located at the crypt bottom. Paneth cells are an essential component in the crypt, which served as… read more here.
Keywords: hpi; intestinal inflammation; paneth cells; crypt ... See more keywords
Mouse Paneth Cell-Enriched Proteome Enabled by Laser Capture Microdissection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00311
Abstract: Paneth cells are antimicrobial peptide-secreting cells located at the base of the crypts of the small intestine. The proteome of Paneth cells is not well defined because of their coexistence with stem cells, making it… read more here.
Keywords: capture microdissection; cell; laser capture; paneth cells ... See more keywords
Paneth cell alertness to pathogens maintained by vitamin D receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.11.015
Abstract: BACKGROUND Vitamin D exerts a regulatory role over mucosal immunity via the vitamin D receptor (VDR). While Paneth cells and their products are known to regulate the commensal and pathogenic microbiota, the role that VDRs… read more here.
Keywords: vdr mice; cell alertness; vdr; paneth cell ... See more keywords
Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2112882
Abstract: ABSTRACT Toll-like receptor 4 (TLR4) has been identified as a potentially promising therapeutic target in acute pancreatitis (AP). However, the role of intestinal TLR4 in AP and AP-associated gut injury remains unclear. This study aimed… read more here.
Keywords: paneth cells; tlr4; intestinal tlr4; gut microbiota ... See more keywords
Implications of Paneth cell dysfunction on gastrointestinal health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000887
Abstract: Purpose of review Paneth cells are specialized, secretory epithelial cells located in the small intestine. Although their existence was first described in 1872, their precise role in the gut remained unclear for over a century.… read more here.
Keywords: cell; disease; paneth cells; dysfunction ... See more keywords
The roles and functions of Paneth cells in Crohn’s disease: A critical review
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DOI: 10.1111/cpr.12958
Abstract: Paneth cells (PCs) are located at the base of small intestinal crypts and secrete the α‐defensins, human α‐defensin 5 (HD‐5) and human α‐defensin 6 (HD‐6) in response to bacterial, cholinergic and other stimuli. The α‐defensins… read more here.
Keywords: cells crohn; roles functions; paneth cells; review ... See more keywords