Pangenome graph construction from genome alignments with Minigraph-Cactus
Sign Up to like & getrecommendations! Published in 2023 at "Nature Biotechnology"
DOI: 10.1101/2022.10.06.511217
Abstract: Pangenome references address biases of reference genomes by storing a representative set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles determined by variant callers can be used to construct pangenome graphs,… read more here.
Keywords: reference; pangenome graph; genome alignments; minigraph cactus ... See more keywords
Pig pangenome graph reveals functional features of non-reference sequences
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Animal Science and Biotechnology"
DOI: 10.1186/s40104-023-00984-4
Abstract: Background The reliance on a solitary linear reference genome has imposed a significant constraint on our comprehensive understanding of genetic variation in animals. This constraint is particularly pronounced for non-reference sequences (NRSs), which have not… read more here.
Keywords: reference sequences; pig pangenome; reference; pangenome graph ... See more keywords