Low Incidence of High-Grade Pancreatic Intraepithelial Neoplasia Lesions in a Crmp4 Gene–Deficient Mouse Model of Pancreatic Cancer
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DOI: 10.1016/j.tranon.2020.100746
Abstract: Pancreatic intraepithelial neoplasia (PanIN), the most common premalignant lesion of the pancreas, is a histologically well-defined precursor to invasive pancreatic ductal adenocarcinoma (PDAC). However, the molecular mechanisms underlying the progression of PanINs have not been… read more here.
Keywords: incidence; grade; crmp4; expression ... See more keywords
Incidence of Pancreatic Intraepithelial Neoplasia in an Autopsy Series
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DOI: 10.1097/mpa.0000000000002027
Abstract: Objectives Pancreatic intraepithelial neoplasia (PanIN) is the currently preferred designation for putative preneoplastic changes in the pancreas. There are few data for the incidence of PanIN in the general population. Our goal was to determine… read more here.
Keywords: panin; incidence; incidence panin; pancreatic intraepithelial ... See more keywords
Abstract A052: Spatially Resolved Insights into epithelial-stromal co-evolution in pancreatic ductal adenocarcinoma
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DOI: 10.1158/1538-7445.pancreatic25-a052
Abstract: Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, the most common of which are Pancreatic Intraepithelial Neoplasia (PanIN). PanINs are microscopic and cannot be detected in live individuals; as such, PanIN characterization has occurred prevalently… read more here.
Keywords: evolution; cancer; ductal adenocarcinoma; epithelial stromal ... See more keywords
Spatial proteomics and transcriptomics reveal early immune cell organization in pancreatic intraepithelial neoplasia
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DOI: 10.1172/jci.insight.191595
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate due to late detection. PDAC arises from precursor microscopic lesions, termed pancreatic intraepithelial neoplasia (PanIN), that develop at least a decade before overt disease; this provides… read more here.
Keywords: panin pdac; spatial proteomics; pancreatic intraepithelial; intraepithelial neoplasia ... See more keywords
Platelet to Lymphocyte Ratio Correlates With Carcinoma Progression in Pancreatic Intra Epithelial Neoplasia
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DOI: 10.21873/anticanres.15611
Abstract: Background/Aim: Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor lesion to pancreatic adenocarcinoma (PDAC). Yet no criteria to quantify patients at risk for progression to PDAC with PanIN exist. Platelet to lymphocyte ratio is… read more here.
Keywords: panin; lymphocyte ratio; progression; platelet lymphocyte ... See more keywords