Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948254
Abstract: Inflammasomes are multimeric protein complex that assemble in the cytosol upon microbial infection or cellular stress. Upon activation, inflammasomes drive the maturation of proinflammatory cytokines, IL‐1β and IL‐18, and also activate the pore‐forming protein, gasdermin… read more here.
Keywords: inflammasome activation; apoptosis; activation; pannexin ... See more keywords
Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin : The contribution of pannexin-1, connexins, and CALHM ATP-release channels to purinergic signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09818-2
Abstract: Purinergic signaling mediated by ATP and its metabolites contributes to various brain physiological processes as well as to several pathological conditions, including neurodegenerative and neurological disorders, such as epilepsy. Among the different ATP release pathways,… read more here.
Keywords: epilepsy; pannexin channels; atp release; pannexin ... See more keywords
Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01623-2
Abstract: Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, is an aggressive cancer with a poor prognosis. Despite current management, the 5-year survival rate for patients with metastatic RMS is ∼30%; underscoring the need… read more here.
Keywords: pannexin regulated; identification pannexin; regulated genes; interactome pathways ... See more keywords
Pannexin-1 in the CNS: emerging concepts in health and disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15004
Abstract: Pannexin-1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non-selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well-characterized with… read more here.
Keywords: panx1; cns emerging; emerging concepts; disease ... See more keywords
Evidence for protein kinase involvement in the 5‐HT–[Ca2+]i–pannexin‐1 signalling pathway in type II glial cells of the rat carotid body
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Physiology"
DOI: 10.1113/ep087411
Abstract: What is the central question of this study? The mammalian carotid body (CB) is a peripheral chemoreceptor organ involved in O2 and CO2/H+ homeostasis. Recent studies suggest that 5‐HT, released from CB receptor cells, can… read more here.
Keywords: carotid body; pannexin; signalling pathway; protein kinase ... See more keywords
Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abg6941
Abstract: Pannexin (PANX) family proteins form large-pore channels that mediate purinergic signaling. We analyzed the cryo-EM structures of human PANX1 in lipid nanodiscs to elucidate the gating mechanism and its regulation by the amino terminus in… read more here.
Keywords: channel; pannexin; pore; movement ... See more keywords
A pannexin 1 channelopathy causes human oocyte death
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aav8731
Abstract: Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death. A vital gene for oocytes Infertility is common in both males and females, but the biological causes of female infertility are not as… read more here.
Keywords: death; pannexin; female infertility; human oocyte ... See more keywords
Pannexin Channel Inhibition: An Evolving Target to Lower Blood Pressure?
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.312566
Abstract: More than 50 years after spironolactone has come on the market its mechanism of action continues to expand. In this issue of Circulation Research , Good et al1 document the discovery that spironolactone is not… read more here.
Keywords: receptor; blocker; pannexin; blood pressure ... See more keywords
TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0413oc
Abstract: &NA; We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient receptor potential, vanilloid‐type, subtype 4)‐channel agonists: 4&agr;PDD (4&agr;‐phorbol‐12,13‐didecanoate) and GSK1016790A. However, the TRPV4‐activated current exhibited… read more here.
Keywords: pannexin channels; pulmonary fibroblasts; atp via; human pulmonary ... See more keywords
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001891
Abstract: Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear. Pannexin 1, expressed by neurons and astrocytes, form nonselective… read more here.
Keywords: hippocampal neuronal; pannexin; activity; astroglial pannexin ... See more keywords
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188135
Abstract: Background Fibrosing diseases are a leading cause of morbidity and mortality worldwide and, therefore, there is a need for safe and effective antifibrotic therapies. Adenosine, generated extracellularly by the dephosphorylation of adenine nucleotides, ligates specific… read more here.
Keywords: fibrosis; tenofovir; liver skin; adenosine ... See more keywords