Pannexin-1 channel “fuels” by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells
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DOI: 10.1007/s11302-020-09706-1
Abstract: An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological mobilization from the bone marrow (BM) into peripheral blood (PB) and subsequent proper homing and engraftment of these cells are crucial for clinical outcomes from… read more here.
Keywords: pannexin channel; mobilization; stem; stem cells ... See more keywords
Pannexin channel 1, P2×7 receptors, and Dimethyl Sulfoxide mediate pain responses in zebrafish
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DOI: 10.1016/j.bbr.2022.113786
Abstract: The zebrafish has been considered an ideal model for studies of complex behaviors since its behavioral repertoire is well described. Therefore, this study evaluated the perceived pain through behavioral changes in zebrafish larvae. Here we… read more here.
Keywords: pannexin channel; pain; dimethyl sulfoxide; behavioral changes ... See more keywords
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
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DOI: 10.1371/journal.pbio.3001891
Abstract: Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear. Pannexin 1, expressed by neurons and astrocytes, form nonselective… read more here.
Keywords: hippocampal neuronal; pannexin; activity; astroglial pannexin ... See more keywords
Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats
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DOI: 10.3389/fnmol.2022.848185
Abstract: Proinflammatory immune cell subsets constitute the majority in the local microenvironment after spinal cord injury (SCI), leading to secondary pathological injury. Previous studies have demonstrated that inflammasomes act as an important part of the inflammatory… read more here.
Keywords: cord injury; neuroprotective effects; spinal cord; injury ... See more keywords