Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin : The contribution of pannexin-1, connexins, and CALHM ATP-release channels to purinergic signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09818-2
Abstract: Purinergic signaling mediated by ATP and its metabolites contributes to various brain physiological processes as well as to several pathological conditions, including neurodegenerative and neurological disorders, such as epilepsy. Among the different ATP release pathways,… read more here.
Keywords: epilepsy; pannexin channels; atp release; pannexin ... See more keywords
Pannexin-1 channels in epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.09.004
Abstract: Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening,… read more here.
Keywords: channels epilepsy; pannexin channels;
Intrapore lipids hydrophobically gate pannexin-1 channels
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DOI: 10.1126/scisignal.abn2081
Abstract: Large-pore channels such as pannexin-1 (PANX1) typically lack pore-lining constriction points, leaving only speculations on how these channels functionally “close.” In this issue of Science Signaling, Kuzuya et al. found that rearrangements in the PANX1… read more here.
Keywords: intrapore lipids; hydrophobically gate; lipids hydrophobically; pannexin channels ... See more keywords
TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts
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DOI: 10.1165/rcmb.2017-0413oc
Abstract: &NA; We previously described several ionic conductances in human pulmonary fibroblasts, including one activated by two structurally distinct TRPV4 (transient receptor potential, vanilloid‐type, subtype 4)‐channel agonists: 4&agr;PDD (4&agr;‐phorbol‐12,13‐didecanoate) and GSK1016790A. However, the TRPV4‐activated current exhibited… read more here.
Keywords: pannexin channels; pulmonary fibroblasts; atp via; human pulmonary ... See more keywords