Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.
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DOI: 10.1002/1878-0261.13427
Abstract: In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and the proteasomal inhibitor bortezomib displayed synergistic therapeutic activity against pediatric and adult high-grade gliomas. Despite the remarkable initial response to this combination, resistance… read more here.
Keywords: adult high; pediatric adult; panobinostat marizomib; gliomas ... See more keywords