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   Articles with "panoptosis" as a keyword



A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

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recommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.70066

Abstract: PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). read more here.

Keywords: panoptosis; signature survival; based signature; glioblastoma multiforme ... See more keywords

An “Outer Piezoelectric and Inner Epigenetic” Logic‐Gated PANoptosis for Osteosarcoma Sono‐Immunotherapy and Bone Regeneration

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recommendations! Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202415814

Abstract: The precise manipulation of PANoptosis, a newly defined cell death pathway encompassing pyroptosis, apoptosis, and necroptosis, is highly desired to achieve safer cancer immunotherapy with tumor‐specific inflammatory responses and minimal side effects. Nonetheless, this objective… read more here.

Keywords: logic gated; panoptosis; immunotherapy; logic ... See more keywords

TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1‐Mediated Neuronal PANoptosis in Spinal Cord Injury

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202407132

Abstract: Spinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis… read more here.

Keywords: degradation; panoptosis; injury; zbp1 ... See more keywords

Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1

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recommendations! Published in 2025 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.70026

Abstract: PANoptosis is involved in various pathological processes, but its role in acute myocardial infarction (AMI) remains unclear. This study aimed to explore the mechanism by which PANoptosis is involved in AMI. GSE172270 was used as… read more here.

Keywords: targets mechanism; panoptosis targets; panoptosis; myocardial infarction ... See more keywords

Integrated Genomics Reveal Potential Resistance Mechanisms of PANoptosis‐Associated Genes in Acute Myeloid Leukemia

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recommendations! Published in 2025 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23886

Abstract: Acute myeloid leukemia (AML) is marked by the proliferation of abnormal myeloid progenitor cells in the bone marrow and blood, leading to low cure rates despite new drug approvals from 2017 to 2018. Current therapies… read more here.

Keywords: resistance; panoptosis; acute myeloid; drug ... See more keywords

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

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recommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-022-00889-0

Abstract: Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attractive approach for treating tumors. However, the influence and… read more here.

Keywords: panoptosis; oxaliplatin based; chemosensitivity; phosphorylated nfs1 ... See more keywords

Mitochondrial orchestration of PANoptosis: mechanisms, disease pathogenesis, and emerging therapeutic frontiers

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02750-z

Abstract: Mitochondria, traditionally known as cellular powerhouses, are now recognized as central regulators of programmed cell death (PCD) and key players in disease pathogenesis. This review synthesizes current knowledge on mitochondrial mechanisms in PANoptosis—a convergent pathway… read more here.

Keywords: panoptosis; mitochondrial orchestration; pathogenesis; cell death ... See more keywords

Characterization of PANoptosis-related genes in Crohn’s disease by integrated bioinformatics, machine learning and experiments

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-62259-w

Abstract: Currently, the biological understanding of Crohn’s disease (CD) remains limited. PANoptosis is a revolutionary form of cell death reported to participate in numerous diseases, including CD. In our study, we aimed to uncover the roles… read more here.

Keywords: crohn disease; panoptosis; related genes; machine learning ... See more keywords

Significance of novel PANoptosis genes to predict prognosis and therapy effect in the lung adenocarcinoma

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-71954-7

Abstract: Lung adenocarcinoma (LUAD) is the dominant histotype of non-small cell lung cancer. Panoptosis, a comprehensive form of programmed cell death, is central to carcinogenesis. In this study, the expression of PANoptosis-related genes (PRGs) and their… read more here.

Keywords: lung adenocarcinoma; panoptosis; analysis; risk ... See more keywords

Combination of bulk RNA and single-cell sequencing unveils PANoptosis-related immunological ecology hallmarks and classification for clinical decision-making in hepatocellular carcinoma

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-73847-1

Abstract: PANoptosis is engaged in the program of immune response and carcinogenicity. Nonetheless, the actual impacts of PANoptosis on clinical management and oncology immunity in hepatocellular carcinoma (HCC) are not fully grasped. RNA-seq-derived computations were conducted… read more here.

Keywords: cell sequencing; single cell; panoptosis; hepatocellular carcinoma ... See more keywords

The PANoptosis-related hippocampal molecular subtypes and key biomarkers in Alzheimer’s disease patients

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-75377-2

Abstract: Alzheimer’s Disease (AD) is a neurodegenerative disorder, and various molecules associated with PANoptosis are involved in neuroinflammation and neurodegenerative diseases. This work aims to identify key genes, and characterize PANoptosis-related molecular subtypes in AD. Moreover,… read more here.

Keywords: alzheimer disease; panoptosis; panoptosis related; molecular subtypes ... See more keywords