Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00889-0
Abstract: Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attractive approach for treating tumors. However, the influence and… read more here.
Keywords: panoptosis; oxaliplatin based; chemosensitivity; phosphorylated nfs1 ... See more keywords
Caspase-6 is a key regulator of cross-talk signal way in PANoptosis in cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13633
Abstract: Cysteinyl aspartate specific proteinase (caspase)-6 belongs to the caspase family and plays a vital role in mediating cell death. Under certain conditions, three pathways of programmed cell death (PCD), including apoptosis, necroptosis, and pyroptosis (PANoptosis),… read more here.
Keywords: key regulator; way; panoptosis; caspase ... See more keywords
Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12828
Abstract: Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma, which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far, approved effective therapy is still lacking in acute… read more here.
Keywords: acute ocular; panoptosis; acute glaucoma; ocular hypertension ... See more keywords
Characteristic of molecular subtypes based on PANoptosis-related genes and experimental verification of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204720
Abstract: Hepatocellular carcinoma (HCC) is a type of liver cancer that originates from liver cells. It is one of the most common types of liver cancer and a leading cause of cancer-related death worldwide. Early detection… read more here.
Keywords: hepatocellular carcinoma; hcc; panoptosis related; analysis ... See more keywords
Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Research"
DOI: 10.32604/or.2023.028964
Abstract: : Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high mortality rate and poor prognosis. PANoptosis is a novel discovery of programmed cell death associated with cancer development.… read more here.
Keywords: hepatocellular carcinoma; hcc; panoptosis related; panoptosis ... See more keywords
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00238
Abstract: Programmed cell death is regulated by evolutionarily conserved pathways that play critical roles in development and the immune response. A newly recognized pathway for proinflammatory programmed cell death called PANoptosis is controlled by a recently… read more here.
Keywords: panoptosis; protein complex; apoptosis necroptosis; pyroptosis apoptosis ... See more keywords
PANoptosis-based molecular clustering and prognostic signature predicts patient survival and immune landscape in colon cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.955355
Abstract: PANoptosis is a newly-discovered cell death pathway that involves crosstalk and co-ordination between pyroptosis, apoptosis, and necroptosis processes. However, the roles of PANoptosis-related genes (PRGs) in prognosis and immune landscape of colon cancer remain widely… read more here.
Keywords: colon cancer; risk; panoptosis; patient survival ... See more keywords
Recent advances in ZBP1-derived PANoptosis against viral infections
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1148727
Abstract: Innate immunity is an important first line of defense against pathogens, including viruses. These pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively), resulting in the induction of inflammatory cell death, are detected by specific… read more here.
Keywords: derived panoptosis; viral infections; zbp1 derived; panoptosis ... See more keywords
Analysis of PANoptosis-Related LncRNA-miRNA-mRNA Network Reveals LncRNA SNHG7 Involved in Chemo-Resistance in Colon Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.888105
Abstract: Colon adenocarcinoma (COAD) is one of the most common malignancies, and its metastatic lesions are the leading cause of death in COAD patients. PANoptosis is a recently identified pathway for programmed cell death implicated in… read more here.
Keywords: metastasis; lncrna snhg7; coad; analysis ... See more keywords
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.331539
Abstract: Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome. This allows all the components of… read more here.
Keywords: pyroptosis apoptosis; ischemia; panoptosis; apoptosis necroptosis ... See more keywords