Characterization of PANoptosis-related genes in Crohn’s disease by integrated bioinformatics, machine learning and experiments
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DOI: 10.1038/s41598-024-62259-w
Abstract: Currently, the biological understanding of Crohn’s disease (CD) remains limited. PANoptosis is a revolutionary form of cell death reported to participate in numerous diseases, including CD. In our study, we aimed to uncover the roles… read more here.
Keywords: crohn disease; panoptosis; related genes; machine learning ... See more keywords
The PANoptosis-related hippocampal molecular subtypes and key biomarkers in Alzheimer’s disease patients
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DOI: 10.1038/s41598-024-75377-2
Abstract: Alzheimer’s Disease (AD) is a neurodegenerative disorder, and various molecules associated with PANoptosis are involved in neuroinflammation and neurodegenerative diseases. This work aims to identify key genes, and characterize PANoptosis-related molecular subtypes in AD. Moreover,… read more here.
Keywords: alzheimer disease; panoptosis; panoptosis related; molecular subtypes ... See more keywords
Identification and validation of PANoptosis-related LncRNAs prognosis system in hepatocellular carcinoma
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DOI: 10.1038/s41598-025-90498-y
Abstract: Hepatocellular carcinoma (HCC) is one of the most common solid malignancies in the world. Due to the limited effectiveness of current drug treatments, further research on HCC is necessary. PANoptosis is defined as an inflammatory… read more here.
Keywords: related lncrnas; panoptosis; hcc; hepatocellular carcinoma ... See more keywords
Development of a PANoptosis-related LncRNAs for prognosis predicting and immune infiltration characterization of gastric Cancer
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DOI: 10.1038/s41598-025-91534-7
Abstract: PANoptosis is a newly discovered form of programmed cell death (PCD), involving the interaction of cellular pyroptosis, apoptosis, and necroptosis. Although PANoptosis plays a significant role in carcinogenesis process, the impact of PANoptosis-related lncRNAs (PANlncRNAs)… read more here.
Keywords: panoptosis; immune infiltration; analysis; gastric cancer ... See more keywords
Identification of a novel PANoptosis-related gene signature for predicting the prognosis in clear cell renal cell carcinoma
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DOI: 10.1097/md.0000000000039874
Abstract: PANoptosis has been shown to play an important role in tumorigenesis and gain more attention. Yet, the prognostic significance of PANoptosis-related genes has not been investigated more in clear cell renal cell carcinoma (ccRCC). The… read more here.
Keywords: panoptosis; related genes; prognosis; risk score ... See more keywords
Development of a PANoptosis‐Related Pathomics Prognostic Model in Ovarian Cancer: A Multi‐Omics Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70958
Abstract: Ovarian cancer (OC) is a high‐mortality gynaecological malignancy, and the role of PANoptosis, a comprehensive cell death mechanism, in its prognosis remains unexplored. This study aims to clarify it, potentially guiding OC diagnosis and treatment.… read more here.
Keywords: pathomics prognostic; panoptosis; related pathomics; prognostic model ... See more keywords
PANoptosis-Related Optimal Model (PROM): A Novel Prognostic Tool Unveiling Immune Dynamics in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Genomics"
DOI: 10.1155/ijog/5595391
Abstract: Background: PANoptosis, a recently characterized inflammatory programmed cell death modality orchestrated by the PANoptosome complex, integrates molecular mechanisms of pyroptosis, apoptosis, and necroptosis. Although this pathway potentially mediates tumor progression, its role in lung adenocarcinoma… read more here.
Keywords: lung adenocarcinoma; panoptosis; optimal model; panoptosis related ... See more keywords
Comprehensive Analysis of the PANoptosis-Related Genes in Stroke Based on Single-Cell RNA-Seq and Spatial Transcriptomics
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DOI: 10.1155/mi/5828665
Abstract: Background PANoptosis is implicated in immunoinflammatory diseases, but its role in cerebral ischemia-reperfusion injury (CIRI) remains unclear. Methods We integrated single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), and bulk RNA-sequencing (bulk RNA-seq) datasets to explore… read more here.
Keywords: single cell; panoptosis; analysis; rna ... See more keywords
Identification and validation of PANoptosis-related biomarkers in Alzheimer’s disease via single-cell RNA sequencing and machine learning
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DOI: 10.1186/s40001-025-03335-3
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with complex underlying mechanisms. PANoptosis, a newly defined form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis, may play a crucial role in AD pathogenesis.… read more here.
Keywords: alzheimer disease; single cell; panoptosis; machine ... See more keywords
Discovery of PANoptosis-related signatures correlates with immune cell infiltration in psoriasis
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DOI: 10.1371/journal.pone.0310362
Abstract: Psoriasis is an inflammatory skin disease that relapses frequently. Keratinocyte apoptosis dysregulation plays a crucial role in the pathological mechanisms of psoriasis. PANoptosis is a process with intermolecular interaction among pyroptosis, apoptosis, and necroptosis. The… read more here.
Keywords: panoptosis; cluster; panoptosis related; cell ... See more keywords
Characteristic of molecular subtypes based on PANoptosis-related genes and experimental verification of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204720
Abstract: Hepatocellular carcinoma (HCC) is a type of liver cancer that originates from liver cells. It is one of the most common types of liver cancer and a leading cause of cancer-related death worldwide. Early detection… read more here.
Keywords: hepatocellular carcinoma; hcc; panoptosis related; analysis ... See more keywords